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ProteomicsPhosphoproteomic Analysis of Lethal Castration Resistant Prostate Cancer Reveals Patient but not Metastatic Site Heterogeneity of Tyrosine Kinase Activation
Tissue lysis was performed as previously described (Drake, J.M., et al. Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression. Proc Natl Acad Sci U S A 109, 1643-1648 (2012)) Briefly, greater than 300 mg of frozen tumor mass was homogenized and sonicated in urea...
ORGANISM(S): Homo sapiens (Human) 
2013-11-21 | PXD000238 | Pride
Tyrosine phosphorylation Human Prostate cancer 
UnknownGenotype-guided tamoxifen dosing increases active metabolite exposure in women with reduced CYP2D6 metabolism: a multicenter study.
Not available
S-EPMC3158597 | biostudies-literature
UnknownCapecitabine and oxaliplatin in the preoperative multimodality treatment of rectal cancer: surgical end points from National Surgical Adjuvant Breast and Bowel Project trial R-04.
Not available
S-EPMC4050205 | biostudies-literature
UnknownMitochondrial myopathy, lactic acidosis, and sideroblastic anemia (MLASA) plus associated with a novel de novo mutation (m.8969G>A) in the mitochondrial encoded ATP6 gene.
Not available
S-EPMC4253070 | biostudies-literature
UnknownRandomized phase II/III trial assessing gemcitabine/carboplatin and methotrexate/carboplatin/vinblastine in patients with advanced urothelial cancer who are unfit for cisplatin-based chemotherapy: EORTC study 30986.
Not available
S-EPMC3255563 | biostudies-literature
UnknownPrimary analysis of the phase II component of a phase I/II dose intensification study using three-dimensional conformal radiation therapy and concurrent chemotherapy for patients with inoperable non-small-cell lung cancer: RTOG 0117.
Not available
S-EPMC2881726 | biostudies-literature
UnknownA standard of care for individuals with PIK3CA-related disorders: An international expert consensus statement.
Not available
S-EPMC8664971 | biostudies-literature
ProteomicsPhospo-proteomic profiling of Castration Resistant Prostate Cancer
The integration of diverse ‘omic’ datasets will increase our understanding of the key signaling pathways that drive disease. Here, we used clinical tissue cohorts corresponding to lethal metastatic castration resistant prostate cancer (CRPC) obtained at rapid autopsy to integrate mutational, transcr...
ORGANISM(S): Homo sapiens (Human) 
2016-08-19 | PXD002286 | Pride
Prostate cancer Human Phosphorylation 
UnknownEnvironmental variability and biodiversity of megabenthos on the Hebrides Terrace Seamount (Northeast Atlantic).
Not available
S-EPMC4083264 | biostudies-literature
GenomicDobyns DBD

Study 1
2R01-NS050375 (PI: DOBYNS, William B.)
The genetic basis of mid-hindbrain malformations
Our general goal for this project is to advance our understanding of human developmental disorders that involve the brainstem and cerebellum - brain structures derived from the embryoni...

phs000455 | dbGaP
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