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MetabolomicsSmall molecule produced by Photorhabdus interferes with ubiquinone biosynthesis in Gram-negative bacteria

We report identification of 3,6-dihydroxy-1,2-benzisoxazole (DHB) in a screen of Photorhabdus and Xenorhabdus, whose symbiotic relationship with eukaryotic nematodes favors secondary metabolites that meet several requirements matching those for clinically useful antibiotics. DHB is produced by Ph...

2024-09-06 | MTBLS10720 | MetaboLights
TranscriptomicsThe sigmaB regulon of B. cereus ATCC14579
The alternative sigma factor sigmaB has an important role in the acquisition of stress-resistance in many gram-positive bacteria. In the foodborne pathogen Bacillus cereus sigmaB is activated strongly upon a heat shock and other stress conditions. Here we describe the identification of the set of si...
ORGANISM(S): Bacillus cereus ATCC 14579 
2010-07-01 | E-GEOD-6005 | biostudies-arrayexpress
TranscriptomicsResponse of Burkholderia cenocepacia to polymyxin B
Response of three strains, K56-2, RSF34, and RSF34 4000B to polymyxin B and baseline changes between the strains
ORGANISM(S): Burkholderia cenocepacia 
2011-06-01 | E-MTAB-720 | biostudies-arrayexpress
GenomicsChryseobacterium sp. IHB B 17019
Chryseobacterium sp. IHB B 17019 genome sequencing and assembly
PRJNA303135 | ENA
TranscriptomicsTranscription profiling of Physcomitrella patens response to UV-B
comparison of gene expression between UV-B irradiated Physcomitrella patens gametophores with their non-irradiated controls in two different UV irradiation fields.
ORGANISM(S): Physcomitrella patens 
2010-04-28 | E-MEXP-2508 | biostudies-arrayexpress
TranscriptomicsA Gram-positive three-component antimicrobial peptide-sensing system
To survive during colonization or infection of the human body, microorganisms must defeat antimicrobial peptides, which represent a key component of innate host defense in phagocytes and on epithelia. However, is not known how the clinically important group of Gram-positive bacteria sense antimicrob...
ORGANISM(S): Staphylococcus epidermidis 
2010-05-26 | E-GEOD-7163 | biostudies-arrayexpress
GenomicsPseudoalteromonas piscicida strain:DE2-B
Pseudoalteromonas piscicida strain:DE2-B Genome sequencing and assembly
PRJNA374735 | ENA
MetabolomicsMetabolic Characteristics of Schisantherin B in Mice with Metabolic-Associated Fatty Liver Disease

Objectives: To observe the pharmacokinetic differences of schisantherin B (STB) in the blood and liver of normal and metabolic-associated fatty liver disease (MAFLD) mice, as well as the changes in CYP450 enzymes in MAFLD mice. Methods: A MAFLD model was established in C57 mice fed with a high-fa...

2025-10-29 | MTBLS13232 | MetaboLights
ProteomicsAn Outer Membrane Protein-Targeting Antibiotic Against Resistant Gram-Negative Bacterial Pathogens
There is an urgent need for novel antibiotics against carbapenem and 3rd generation cephalosporin-resistant Gram-negative pathogens, for which the last-resort antibiotics have lost most of their efficacy. We describe here a novel class of synthetic antibiotics that was inspired from natural product-...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2020-02-04 | MSV000084899 | MassIVE
TranscriptomicsDifferential Targeting of the E-Cadherin and b-Catenin Complex by Gram-positive Probiotic Lactobacilli Improves Epithelial Barrier Function
The intestinal ecosystem is balanced by dynamic interactions between resident and incoming microbes, the gastrointestinal barrier, and the mucosal immune system. However, in the context of inflammatory bowel diseases (IBD) where the integrity of the gastrointestinal barrier is compromised, resident ...
ORGANISM(S): Homo sapiens 
2012-02-10 | E-MEXP-3445 | biostudies-arrayexpress
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