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MetabolomicsSmall molecule produced by Photorhabdus interferes with ubiquinone biosynthesis in Gram-negative bacteria

We report identification of 3,6-dihydroxy-1,2-benzisoxazole (DHB) in a screen of Photorhabdus and Xenorhabdus, whose symbiotic relationship with eukaryotic nematodes favors secondary metabolites that meet several requirements matching those for clinically useful antibiotics. DHB is produced by Ph...

2024-09-06 | MTBLS10720 | MetaboLights
ProteomicsAn Outer Membrane Protein-Targeting Antibiotic Against Resistant Gram-Negative Bacterial Pathogens
There is an urgent need for novel antibiotics against carbapenem and 3rd generation cephalosporin-resistant Gram-negative pathogens, for which the last-resort antibiotics have lost most of their efficacy. We describe here a novel class of synthetic antibiotics that was inspired from natural product-...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2020-02-04 | MSV000084899 | MassIVE
ProteomicsDual-acting IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance
Isoprenoids are vital to all organisms in supporting core functions of life, like respiration and membrane stability. IspH, an enzyme in the methyl erythritol phosphate pathway of isoprenoid synthesis, is essential to gram-negative bacteria, mycobacteria and apicomplexans. The IspH substrate, HMBPP,...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2020-10-22 | MSV000086359 | MassIVE
TranscriptomicsCritically ill patients with either gram-positive sepsis or gram-negative sepsis
Objective: It is unclear whether the host response of gram-positive sepsis differs from gram-negative sepsis at a transcriptome level. Using microarray technology, we compared the gene-expression profiles of gram-positive sepsis and gram-negative sepsis in critically ill patients. Design: A pros...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-6535 | biostudies-arrayexpress
TranscriptomicsProfiling the circulating miRNAs in mice exposed to gram-positive and gram-negative bacteria by Illumina small RNA deep sequencing
We profiled the expression of circulating microRNAs (miRNAs) in mice exposed to gram-positive and gram-negative bacteria using Illumina small RNA deep sequencing. Recombinant-specific gram-negative pathogen Escherichia coli (Xen14) and gram-positive pathogen Staphylococcus aureus (Xen29) were used ...
ORGANISM(S): Mus musculus 
2014-08-19 | E-GEOD-60492 | biostudies-arrayexpress
GenomicsGram negative bacilli
Gram negative bacilli Genome sequencing
PRJNA353060 | ENA
GenomicsGram-negative bacteria
Gram-negative bacteria Genome sequencing and assembly
PRJNA1076895 | ENA
GenomicsGram negative Bacilli
Characterization of carbapenemase-producing Gram negative Bacilli Assembly
PRJNA391501 | ENA
Genomicsgram-negative
Resistant gram-negative bacteria in hospitals in Iraq Genome sequencing and assembly
PRJNA1294745 | ENA
GenomicsGram-negative bacilli
Metagenomes containing gram-negative bacilli from positive blood culture broths
PRJNA877287 | ENA
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