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MetabolomicsSmall molecule produced by Photorhabdus interferes with ubiquinone biosynthesis in Gram-negative bacteria

We report identification of 3,6-dihydroxy-1,2-benzisoxazole (DHB) in a screen of Photorhabdus and Xenorhabdus, whose symbiotic relationship with eukaryotic nematodes favors secondary metabolites that meet several requirements matching those for clinically useful antibiotics. DHB is produced by Ph...

2024-09-06 | MTBLS10720 | MetaboLights
ProteomicsDual-acting IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance
Isoprenoids are vital to all organisms in supporting core functions of life, like respiration and membrane stability. IspH, an enzyme in the methyl erythritol phosphate pathway of isoprenoid synthesis, is essential to gram-negative bacteria, mycobacteria and apicomplexans. The IspH substrate, HMBPP,...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2020-10-22 | MSV000086359 | MassIVE
ProteomicsAn Outer Membrane Protein-Targeting Antibiotic Against Resistant Gram-Negative Bacterial Pathogens
There is an urgent need for novel antibiotics against carbapenem and 3rd generation cephalosporin-resistant Gram-negative pathogens, for which the last-resort antibiotics have lost most of their efficacy. We describe here a novel class of synthetic antibiotics that was inspired from natural product-...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2020-02-04 | MSV000084899 | MassIVE
TranscriptomicsProfiling the circulating miRNAs in mice exposed to gram-positive and gram-negative bacteria by Illumina small RNA deep sequencing
We profiled the expression of circulating microRNAs (miRNAs) in mice exposed to gram-positive and gram-negative bacteria using Illumina small RNA deep sequencing. Recombinant-specific gram-negative pathogen Escherichia coli (Xen14) and gram-positive pathogen Staphylococcus aureus (Xen29) were used ...
ORGANISM(S): Mus musculus 
2014-08-19 | E-GEOD-60492 | biostudies-arrayexpress
GenomicsGram-negative bacteria
Gram-negative bacteria Genome sequencing and assembly
PRJNA1076895 | ENA
TranscriptomicsCirculating miRNA expression after subcutaneous injection of Gram negative and positive bacteria in the mice
To explore the circulating miRNA expression after subcutaneous injection of Gram negative and positive bacteria in the mice The recombinant specific Gram negative pathogens Escherichia coli (xen14) and Gram positive pathogens Staphyllococcus aureus (xen29) were purchased from the Caliper (Caliper, P...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-49189 | biostudies-arrayexpress
GenomicsCarbapenem-susceptible Gram negative bacteria
Carbapenem-susceptible Gram negative bacteria sequences from a Singapore Hospital
PRJNA1281836 | ENA
Genomicsgram-negative
Resistant gram-negative bacteria in hospitals in Iraq Genome sequencing and assembly
PRJNA1294745 | ENA
TranscriptomicsA Gram-positive three-component antimicrobial peptide-sensing system
To survive during colonization or infection of the human body, microorganisms must defeat antimicrobial peptides, which represent a key component of innate host defense in phagocytes and on epithelia. However, is not known how the clinically important group of Gram-positive bacteria sense antimicrob...
ORGANISM(S): Staphylococcus epidermidis 
2010-05-26 | E-GEOD-7163 | biostudies-arrayexpress
MetabolomicsMetabolomic and Proteomic Profiling of the Antimicrobial Potentials from Lactobacillus johnsonii KD1 Cell-Free Supernatant against Foodborne Pathogenic Bacteria

This study characterized functions and metabolic profiles of cell-free supernatants (CFS) from Lactobacillus johnsonii KD1 against three foodborne pathogens: the Gram-negative bacteria Vibrio parahaemolyticus 3HP and Salmonella enterica serovar ...

2026-09-24 | MTBLS14550 | MetaboLights
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