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TranscriptomicsGene expression signature of c-MYC-immortalized human fibroblasts reveals loss of growth inhibitory response to TGFb
Cancer cells exhibit the ability to proliferate indefinitely, but paradoxically, overexpression of cellular oncogenes in primary cells can result in a rapid and irreversible cell cycle arrest known as oncogene-induced senescence (OIS). However, we have shown that constitutive overexpression of the o...
ORGANISM(S): Homo sapiens 
2011-08-03 | E-GEOD-31002 | biostudies-arrayexpress
TranscriptomicsExpression data from human colon cancer cell line HCT116 with NFX1-91 knockdown and control cells
NFX1-91, a novel E6 cellular downstream target, functions as a transcriptional regulator and is involved in repressing hTERT expression. Other functions and downstream targets regulated by NFX1-91 were not well understood. We used microarrays to determine gene expression deregulated when NFX1-91 wa...
ORGANISM(S): Homo sapiens 
2010-08-18 | E-GEOD-23674 | biostudies-arrayexpress
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Cell NAMPTi treatment)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7251 | MetaboLights
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