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TranscriptomicsMCL1 is deregulated in subgroups of diffuse large B-cell lymphoma
MCL1 is an anti-apoptotic member of the BCL2 family that is deregulated in various solid and hematological malignancies. However, its role in the molecular pathogenesis of diffuse large B-cell lymphoma (DLBCL) is unclear. We analyzed gene expression profiling data from 350 DLBCL patient samples and ...
ORGANISM(S): Homo sapiens 
2013-01-04 | E-GEOD-43272 | biostudies-arrayexpress
TranscriptomicsExpression data from treatment-induced senescence in mouse Emu-myc B-cell lymphoma model
Treatment induced senescence (TIS) is a terminal cell cycle arrest program, increasingly recognized as a tumor suppressor mechanism complementing apoptosis in response to standard chemotherapy regimens. In particular cells with blocked apoptotic pathways rely on senescence as the only remaining fail...
ORGANISM(S): Mus musculus 
2011-11-21 | E-GEOD-31099 | biostudies-arrayexpress
TranscriptomicsSliding of Bacillus subtilis Natto
Transcriptome comparison of Bacillus subtilis Natto under sliding permissive (0.7% agar) and restrictive (1.5% agar or spo0A mutant strain) conditions. B subtilis Natto wild type cells were grown on the top of LB solid medium with 1.5% and 0.7% agar concentration (samples 1-4). B subtilis Natto wild...
ORGANISM(S): Bacillus subtilis subsp. natto 
2015-08-04 | E-GEOD-43840 | biostudies-arrayexpress
TranscriptomicsAccess to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B cell activation and proliferation
In human chronic lymphocytic leukemia (CLL) pathogenesis B cell antigen receptor signaling seems important for leukemia B cell ontogeny, whereas the microenvironment influences B cell activation, tumor cell lodging and provision of antigenic stimuli. Using the murine E?-Tcl1 CLL model, we demonstrat...
ORGANISM(S): Mus musculus 
2014-09-01 | E-GEOD-60925 | biostudies-arrayexpress
TranscriptomicsPTEN loss deM-oM-,M-^Anes a PI3K/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL) represents a heterogeneous diagnostic category with distinct molecular subtypes that can be deM-oM-,M-^Aned by gene expression proM-oM-,M-^Aling. However, even within these deM-oM-,M-^Aned subtypes, heterogeneity prevails. To further elucidate the pathogenesis o...
ORGANISM(S): Homo sapiens 
2013-07-09 | E-GEOD-45495 | biostudies-arrayexpress
TranscriptomicsOncogenic CARMA1 couples NF-κB and β-Catenin signaling in diffuse large B cell lymphomas
Constitutive activation of the anti-apoptotic NF-κB signaling pathway is a hallmark of the activated B-cell-like (ABC) subtype of diffuse large B-cell lymphomas (DLBCL) that is characterized by adverse survival. Recurrent oncogenic mutations are found in the scaffold protein CARMA1 (CARD11) that co...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-70025 | biostudies-arrayexpress
UnknownCritical role of PI3K signaling for NF-kappaB-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells.
Not available
S-EPMC3017191 | biostudies-literature
UnknownA gammaherpesvirus Bcl-2 ortholog blocks B cell receptor-mediated apoptosis and promotes the survival of developing B cells in vivo.
Not available
S-EPMC3916410 | biostudies-literature
UnknownReversible Small Molecule Inhibitors of MAO A and MAO B with Anilide Motifs.
Not available
S-EPMC6996489 | biostudies-literature
UnknownPTEN loss defines a PI3K/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphoma.
Not available
S-EPMC3725065 | biostudies-literature
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