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ProteomicsComparative proteomic profiling identifies reciprocal expression of mitochondrial proteins between white and grey matter lesions from multiple sclerosis brains
Multiple Sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central nervous system (CNS), where ongoing demyelination and remyelination failure are the major factors for progressive neurological disability. In this report, we employed a comprehensive proteomic approach and imm...
ORGANISM(S): Homo sapiens (Human) 
2021-12-21 | PXD029285 | Pride
Multiple sclerosis Mass spectrometry Gray matter lesion White matter lesion Mitochondria 
TranscriptomicsTranscript Profiles of Microglia/Macrophage Cells at the Borders of Chronic Active and Subpial Gray Matter Lesions in Multiple Sclerosis
Microglia/macrophages line the border of demyelinated lesions in both cerebral white matter and cortex in multiple sclerosis brains. Microglia/macrophages associated with chronic white-matter lesions are thought to be responsible for slow lesion expansion and disability progression in progressive mu...
ORGANISM(S): Homo sapiens 
2024-05-05 | GSE255290 | GEO
UnknownGray matter atrophy in multiple sclerosis despite clinical and lesion stability during natalizumab treatment.
Not available
S-EPMC6303064 | biostudies-literature
UnknownAPOL1 renal-risk variants associate with reduced cerebral white matter lesion volume and increased gray matter volume.
Not available
S-EPMC4946987 | biostudies-literature
UnknownSubcortical deep gray matter pathology in patients with multiple sclerosis is associated with white matter lesion burden and atrophy but not with cortical atrophy: a diffusion tensor MRI study.
Not available
S-EPMC7964539 | biostudies-literature
UnknownEffect of Cyclosporine on Lesion Growth and Infarct Size within the White and Gray Matter.
Not available
S-EPMC5406390 | biostudies-literature
GenomicsTranscript Profiles of Microglia/Macrophage Cells at the Borders of Chronic Active and Subpial Gray Matter Lesions in Multiple Sclerosis
Transcript Profiles of Microglia/Macrophage Cells at the Borders of Chronic Active and Subpial Gray Matter Lesions in Multiple Sclerosis
PRJNA1074380 | ENA
TranscriptomicsGene expression profiles in the spinal cord below the lesion level and influence of treadmill locomotor training
Traumatic spinal cord injury (SCI) often leads to loss of locomotor function. Neuroplasticity of spinal circuitry underlies some functional recovery and therefore represents a therapeutic target to improve locomotor function following SCI. However, the cellular and molecular mechanisms mediating neu...
ORGANISM(S): Rattus norvegicus 
2013-11-27 | E-GEOD-52763 | biostudies-arrayexpress
UnknownWhite and gray matter contributions to executive function recovery after traumatic brain injury.
Not available
S-EPMC4395886 | biostudies-literature
UnknownA Longitudinally Extensive Spinal Cord Lesion Restricted to Gray Matter in an Adolescent Male.
Not available
S-EPMC6435483 | biostudies-literature
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