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TranscriptomicsMicroRNA expression profiling of human breast cancer identifies new markers of tumour subtype
MicroRNAs (miRNAs), a class of short non-coding RNAs, often act post-transcriptionally to inhibit gene expression. We used a bead-based flow cytometric profiling method to obtain miRNA expression data for 93 primary human breast tumours, 21 cell lines and five normal breast samples. Of 309 human miR...
ORGANISM(S): Homo sapiens 
2007-10-09 | E-GEOD-7842 | biostudies-arrayexpress
TranscriptomicsBET Protein Inhibition shows Efficacy Against JAK2V617F-Driven Neoplasms
Small molecule inhibition of the BET family of proteins, which bind acetylated lysines within histones, has been shown to have a marked therapeutic benefit in pre-clinical models of MLL-fusion protein driven leukemias. Here, we report that I-BET151, a highly specific BET family bromodomain inhibitor...
ORGANISM(S): Homo sapiens 
2013-08-20 | E-MTAB-1817 | biostudies-arrayexpress
TranscriptomicsSetD8 Knockdown in M-CM-^_-estradiol-treated (24 h) G1E-ER-GATA-1 cells
The establishment and maintenance of cell type-specific transcriptional programs require an ensemble of broadly expressed chromatin remodeling and modifying enzymes. Many questions remain unanswered regarding the contributions of these enzymes to specialized genetic networks that control critical pr...
ORGANISM(S): Mus musculus 
2013-07-24 | E-GEOD-49174 | biostudies-arrayexpress
TranscriptomicsHigh resolution array-CGH and expression profiling identifies a novel genomic subtype of ER negative breast cancer
An oligo array based high-resolution analysis of copy number alterations in 171 primary breast tumors of relatively small size and low NPI, and 49 breast cancer cell-lines. Objectives of the study were to study the molecular taxonomy and the genomic aberration patterns in a breast cancer cohort repr...
ORGANISM(S): Homo sapiens 
2007-08-16 | E-GEOD-8757 | biostudies-arrayexpress
TranscriptomicsMicroRNAs expression profiling during breast cancer progression
MicroRNAs (miRNAs) are known to be deregulated in human breast cancer (BC). The purpose of the current study was to investigate the expression of miRNAs in different stages of BC to assess their biological value in BC progression. MiRNA expression was assessed in a series of BC patients (n=7) with d...
ORGANISM(S): Homo sapiens 
2012-06-22 | E-GEOD-38867 | biostudies-arrayexpress
GenomicsMassive genomic rearrangement acquired in a single catastrophic event during cancer development - samples
Massive genomic rearrangement acquired in a single catastrophic event during cancer development
EGAD00001000002 | EGA
GenomicsMassive Genomic Rearrangment Acquired in a Single Catastrophic Event During Cancer Development
Cancer is driven by mutation. Using Agilent exome hybridisation capture and Illumina GA massively parallel sequencing technology, we aim to sequence ~1600 microRNAs plus the protein coding genome of 25 matched human renal cancer samples. Bespoke algorithms are being developed to identify the somatic...
EGAS00000000029 | EGA
TranscriptomicsRobust enumeration of cell subsets from tissue expression profiles (BeadChip)
We introduce CIBERSORT, a method for characterizing cell composition of complex tissues from their gene expression profiles. When applied to enumeration of hematopoietic subsets in RNA mixtures from fresh, frozen, and fixed tissues, including solid tumors, CIBERSORT outperformed other methods with r...
ORGANISM(S): Homo sapiens 
2015-03-29 | E-GEOD-65133 | biostudies-arrayexpress
Genomicsena-DATASET-CRUK-CI-16-05-2016-12:25:56:672-139 - samples
Targeted sequencing of 173 genes in 2433 primary breast tumours. Data includes 2433 tumour samples, 523 adjacent normal (breast) samples and 127 blood samples. Libraries were prepared with Illumina's Nextera custom enrichment kit targetting all the exons of the most frequently mutated breast cance...
EGAD00001002115 | EGA
GenomicsMETABRIC: Data from Pereira et al (2016), The somatic mutation profiles of 2433 breast cancers refine their genomic and transcriptomic landscapes. Nat Comms 7.
The genomic landscape of breast cancer is complex, and inter- and intra-tumour heterogeneity are important challenges in treating the disease. In this study, we sequence 173 genes in 2433 primary breast tumours that have copy number aberration (CNA), gene expression, and long-term clinical follow-u...
EGAS00001001753 | EGA
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