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TranscriptomicsqRT-PCR of ex vivo Salmonella enterica in NRAMP-1 minus/plus macrophage background
A major virulence factor in S. enterica is the pathogenicity island Spi2. The goal of the experiment was to determine the impact of the NRAMP-1 (natural resistance-associated macrophage protein-1) on expression of Spi2 in S. enterica wild type (WT) and triple mutant strain (TMS) with deletions in SP...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 
2011-06-13 | E-GEOD-26806 | biostudies-arrayexpress
TranscriptomicsqRT-PCR of ex vivo Salmonella enterica in TLR4 minus/plus macrophage background
A major virulence factor in S. enterica is the pathogenicity island Spi2. The goal of the experiment was to determine the impact of the toll-like receptor 4 (TLR-4) on expression of Spi2 in S. enterica wild type (WT) and triple mutant strain (TMS) with deletions in SPI-1 TTSS, SPI-2 TTSS, flagella....
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 
2011-06-13 | E-GEOD-26804 | biostudies-arrayexpress
TranscriptomicsSalmonella enterica subsp. Enteric sv. Typhimurium in vivo induced enterocyte transcriptional response
1-day-old C57BL/6 mice were left untreated (co) or orally infected with 10E2 CFU wildtype (wt) or delta invC SPI1 mutant Salmonella Typhimurium (ATCC14028). Four biological replicates obtained from individual animals were exmained; each group contained animals from at least 2 different litters. On d...
ORGANISM(S): Mus musculus 
2014-09-01 | E-GEOD-51160 | biostudies-arrayexpress
TranscriptomicsMicroarray (one-color) gene expression analysis of Euglena gracilis subjected to altered acceleration during parabolic flight
Euglena gracilis is a unicellular freshwater flagellate, which uses the gravitational vector for orientation in the water column in the dark. This allows the cell to reach areas in the water column for reproduction and growth. How exactly the gravitational vector is perceived, and which intracellula...
ORGANISM(S): Euglena gracilis 
2019-07-09 | E-MTAB-8064 | biostudies-arrayexpress
TranscriptomicsThe effect of alpha, beta, gamma interferon receptors on host reponse to influenza virus in mouse embryonic fibroblasts
The objective of this study was to examine the host transcriptional response to high and low pathogenecity viruses in mouse embryonic fibroblasts (MEFs) isolated from different mouse genetic backgrounds to further understand the contribution of interferon signaling pathways to host response to influ...
ORGANISM(S): Mus musculus 
2012-04-29 | E-GEOD-37665 | biostudies-arrayexpress
TranscriptomicsAcute host transcriptonal response to A/Texas/36/91 influenza and A/Texas/36/91 influenza containing the NS1 gene from r1918 in A549 cells
The M-bM-^@M-^\Spanish influenzaM-bM-^@M-^] of 1918 claimed an unprecedented number of lives, yet the determinants of virulence for this virus are still not fully understood. Here, we used functional genomics and an in vitro human lung epithelial cell infection model to define the global host transc...
ORGANISM(S): Homo sapiens 
2012-05-13 | E-GEOD-37829 | biostudies-arrayexpress
TranscriptomicsMolecular signatures associated with Mx1-mediated resistance to highly pathogenic influenza virus infection: mechanisms of survival
Understanding the role of host factors during lethal influenza virus infection is critical to deciphering the events that will determine the fate of the host. One such factor is encoded by the Mx1 gene, which confers resistance to influenza virus infection. Here, we compared pathology and global gen...
ORGANISM(S): Mus musculus 
2012-02-20 | E-GEOD-35933 | biostudies-arrayexpress
TranscriptomicsAcute host transcriptonal response to r1918 influenza and r1918 influenza containing the NS1 gene from A/Texas/36/91 in A549 cells
The “Spanish influenza” of 1918 claimed an unprecedented number of lives, yet the determinants of virulence for this virus are still not fully understood. Here, we used functional genomics and an in vitro human lung epithelial cell infection model to define the global host transcriptional response t...
ORGANISM(S): Homo sapiens 
2012-05-13 | E-GEOD-37951 | biostudies-arrayexpress
TranscriptomicsRNAseq Analysis of Transcriptomic Response to Zn Resupply in Chlamydomonas reinhardtii
Zn-limited cells accumulate Cu in intracellular structures in a reversable manner. We used RNAseq analysis to monitor gene expression in Zn-limited cells, and during a time course (0 - 24 h) after Zn resupply. Comparison of Chlamydomonas reinhardtii gene expression when Zn deficient cells are resup...
ORGANISM(S): Chlamydomonas reinhardtii 
2014-11-01 | E-GEOD-58786 | biostudies-arrayexpress
UnknownImpact of Complete Revascularization in the ISCHEMIA Trial.
Not available
S-EPMC10529674 | biostudies-literature
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