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Multiple cancers may arise from within a clonal region of preneoplastic epithelium, a phenomenon termed M-^Qfield changeM-^R. However, it is not known how field change develops. We investigate this question and analyse the behavior of scattered single esophageal epithelial progenitor cells expressi...
ORGANISM(S): Mus musculus 
To assess the transcriptional profile within tumours AhcreERTR26flEYFP/wt LSL Kras+/G12D animals were treated with diethylnitrosamine for 8 weeks prior to induction of the Kras allele with a single dose of β-naphthoflavone (20 mg/kg) and tamoxifen (0.25 mg). Subsequently, animals were treated with...
ORGANISM(S): Mus musculus 
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