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ProteomicsEpigenetic Silencing by SETDB1 Suppresses Tumor-cell Intrinsic Immunogenicity
Griffin GK, Wu J, Iracheta-Vellve A, Patti JC, Hsu J, Davis T, Dele-Oni D, Du PP, Halawi A, Ishizuka JJ, Kim S, Klaeger S, Knudsen NH, Miller BC, Nguyen T, Olander K, Papanastasiou M, Rachimi S, Robitschek EJ, Schneider EM, Yeary M, Zimmer M, Jaffe JD, Carr SA, Doench JG, Haining WN, Yates KB, Mangu...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-12-11 | MSV000086580 | MassIVE
GenomicsA PTIP-PA1 subcomplex promotes transcription for IgH class-switching independently from the associated MLL3/MLL4 methyltransferase complex
Class-switch recombination (CSR) diversifies antibodies for productive immune responses while maintaining stability of the B cell genome. Transcription at the immunoglobulin heavy-chain (Igh) locus targets CSRassociated DNA damage and is promoted by the BRCT domain-containing PTIP protein. Although ...
ORGANISM(S): Mus musculus 
2015-12-12 | E-GEOD-75930 | biostudies-arrayexpress
ProteomicsMatched Lung Tumor And Emphysematous Matrix Proteomics, Transcriptomics, and Translatomics
Chronic obstructive pulmonary disease (COPD) is a known risk factor for developing lung cancer suggesting that the COPD stroma contains factors supporting tumorigenesis. Since cancer initiation is complex we used a multi-omic approach to identify gene expression patterns that distinguish COPD stroma...
ORGANISM(S): Homo sapiens (Human) 
2019-05-28 | PXD007919 | Pride
Translatomics Copd Lung cancer Data integration Transcriptomics Rna Jive Proteomics Emphysema 
ProteomicsTwo cancer-promoting stromal gene expression programs depend on lung function
Chronic obstructive pulmonary disease (COPD) is an independent risk factor for lung cancer, suggesting that COPD stroma favors cancer initiation. Therefore, we used proteomics and polysome-profiling to identify gene expression programs that distinguish stroma of patients harboring lung cancer from t...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD007743 | Pride
Human Translatomics Copd Lung tissue Transcriptomics Proteomics Emphysema Lung cancer 
TranscriptomicsHybrid Mouse diversity Panel Liver Expression Profile
Novel, systems-based approach to mouse genetics. Expression Profiles from 99 strains of inbred and recombinant inbred mice. Most assayed in triplicate. Two of 288 chips were excluded from the final analysis due to low QC scores.
ORGANISM(S): Mus musculus 
2010-05-19 | E-GEOD-16780 | biostudies-arrayexpress
GenomicsThe p23 molecular chaperone and GCN5 acetylase jointly modulate protein-DNA dynamics and open chromatin status.
Dense mapping of individual DNase I cleavages from intact nuclei isolated from wild type, sba1M-NM-^T and gcn5M-NM-^T yeast using high-throughput sequencing. Open chromatin status of wild type, sba1-/- and gcn5-/- yeast strains were generated by Dnase-seq.
ORGANISM(S): Saccharomyces cerevisiae 
2012-08-23 | E-GEOD-40255 | biostudies-arrayexpress
GenomicsHighly integrated single base resolution maps of the epigenome in Arabidopsis
Whole genome shotgun bisulfite sequencing, small RNA sequencing and transcriptome sequencing of wildtype Arabidopsis plants (Col-0), and met1, drm1 drm2 cmt3, and ros1 dml2 dml3 null mutants using the Illumina Genetic Analyzer. A comparison was performed with regions of the genome containing cytosin...
ORGANISM(S): Arabidopsis thaliana 
2008-04-20 | E-GEOD-10877 | biostudies-arrayexpress
TranscriptomicsMacrophage samples from the HMDP
Identify genes involved in regulation of inflammatory responses and gene-environemnt interactions, in macrophages from a set of mouse inbred strains termed the HMDP. The HMDP is a genetically diverse mapping panel comprised of classical inbred and recombinant inbred wild type mice. The RMA values o...
ORGANISM(S): Mus musculus 
2012-10-26 | E-GEOD-38705 | biostudies-arrayexpress
TranscriptomicsPhase I study of Veliparib in combination with Cisplatin and Vinorelbine for patients with advanced triple-negative breast cancer (TNBC) and/or BRCA mutation-associated breast cancer
PURPOSE: Preclinically, cisplatin is synergistic with vinorelbine and the poly(ADP-ribose) polymerase (PARP) inhibitor veliparib, and has anti-neoplastic activity in TNBC and BRCA mutation-associated breast cancer. This phase I study assessed veliparib with cisplatin and vinorelbine. PATIENTS AND M...
ORGANISM(S): Homo sapiens 
2015-09-09 | E-GEOD-72795 | biostudies-arrayexpress
UnknownOutcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study.
Not available
S-EPMC8634634 | biostudies-literature
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