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TranscriptomicsGenome-scale Analysis of E. coli FNR Reveals Complex Features of Transcription Factor Binding
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2013-06-20 | E-GEOD-41195 | biostudies-arrayexpress
TranscriptomicsApc restoration promotes cellular differentiation and reestablishes crypt homeostasis in colorectal cancer
The Adenomatous Polyposis Coli (APC) tumor suppressor is mutated in the vast majority of human colorectal cancers (CRC) and leads to deregulated Wnt signaling. To determine whether Apc disruption is required for tumor maintenance, we developed a mouse model of CRC whereby Apc can be conditionally su...
ORGANISM(S): Mus musculus 
2015-06-18 | E-GEOD-67186 | biostudies-arrayexpress
TranscriptomicsFunctional Evidence Implicating Chromosome 7q22 Haploinsufficiency in Myelodysplastic Syndrome Pathogenesis
Purpose: 5A3+/del mice, which have a heterozygous germ line deletion of a 2-Mb interval of chromosome band 5A3 syntenic to a commonly deleted segment of human 7q22, exhibit hematopoietic stem cell (HSC) abnormalities that may contribute to myelodysplastic syndrome (MDS) pathogenesis. These defects a...
ORGANISM(S): Mus musculus 
2015-09-09 | E-GEOD-72811 | biostudies-arrayexpress
GenomicsGenome-wide analysis of FNR and M-OM-^C70 in E. coli under aerobic and anaerobic growth conditions.
We found many binding sites for FNR under glucose fermentative anaerobic growth conditions. Also, many binding sites were identified for M-OM-^C70 under both aerobic and anaerobic growthin conditions. Descirbed in the manuscript "Genome-scale Analysis of E. coli FNR Reveals the Complexity of B...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2013-06-20 | E-GEOD-41187 | biostudies-arrayexpress
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