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Transcriptomicsc-Src Modulates Estrogen-Induced Stress and Apoptosis in Estrogen-Deprived Breast Cancer Cells [MCF-7:5C]
The emergence of anti-estrogen resistance in breast cancer is an important clinical phenomenon affecting long-term survival in this disease. Identifying factors that convey cell survival in this setting may guide improvements in treatment. Estrogen (E2) can induce apoptosis in breast cancer cells th...
ORGANISM(S): Homo sapiens 
2014-07-18 | E-GEOD-59535 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing reveals oligodendrocyte and neuronal transcripts in microglia relevant to central nervous system disease
Expression profiling of distinct central nervous system (CNS) cell populations has been employed to facilitate disease classification and to provide insights into the molecular basis of brain pathology. One important cell type implicated in a wide variety of CNS disease states is the resident brain ...
ORGANISM(S): Mus musculus 
2015-01-30 | E-GEOD-53789 | biostudies-arrayexpress
TranscriptomicsF11R is a novel monocyte prognostic biomarker for malignant glioma [Affymetrix]
Objective: Brain tumors (gliomas) contain large populations of infiltrating macrophages and recruited microglia, which in experimental murine glioma models promote tumor formation and progression. Among the barriers to understanding the contributions of these stromal elements to high-grade glioma (g...
ORGANISM(S): Mus musculus 
2013-11-13 | E-GEOD-46686 | biostudies-arrayexpress
TranscriptomicsF11R is a novel monocyte prognostic biomarker for malignant glioma [Seq]
Objective: Brain tumors (gliomas) contain large populations of infiltrating macrophages and recruited microglia, which in experimental murine glioma models promote tumor formation and progression. Among the barriers to understanding the contributions of these stromal elements to high-grade glioma (g...
ORGANISM(S): Mus musculus 
2013-11-13 | E-GEOD-46688 | biostudies-arrayexpress
Genomicsena-DATASET-MGH-10-02-2015-15:17:58:985-1 - samples
DNA was derived from the primary tumour, lung metastasis, and peri-aortic lymph node metastasis. DNA from the spleen was used as a normal control. For WE sequencing we user Hybrid capture (Nimblegen version 3.0) of the lymph node and lung metastases, primary tumour and spleen normal; we generated ~1...
EGAD00001001252 | EGA
Genomicsena-DATASET-MGH-10-02-2015-15:19:45:352-2 - samples
DNA was derived from the primary tumour, lung metastasis, and peri-aortic lymph node metastasis. DNA from the spleen was used as a normal control. WG sequencing produced ~30-fold (primary tumour, spleen normal)-50-fold (lung metastasis) coverage
EGAD00001001253 | EGA
GenomicsMemorial Sloan Kettering Cancer Center - Human Oncology & Pathogenesis Program (HOOP) - Data Access Committee
Data Access Committee EGAC00001000305
EGAC00001000305 | EGA
GenomicsTherapeutic Resistance to PI3K-alpha Inhibitors
We have studied the tumor genomic evolution in a patient with metastatic breast cancer bearing an activating PIK3CA mutation. The patient was treated with the PI3Kα inhibitor BYL719 and achieved a lasting clinical response on BYL719, but eventually progressed to treatment and died shortly thereafter...
EGAS00001000991 | EGA
GenomicsEvolution of an adenomacarcinoma in response to selection by targeted kinase inhibitors
Background - Adenocarcinomas of the tongue are rare and represent the minority (20-25%) of salivary gland tumors affecting the tongue. We investigated the utility of massively parallel sequencing to characterize an adenocarcinoma of the tongue, before and after treatment. R...
EGAS00000000074 | EGA
GenomicsEGAD00000000045
Genomic sequencing and transcriptome shotgun sequencing of a metastatic tumour and its recurrence after drug therapy in a single patient
EGAD00000000045 | EGA
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