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TranscriptomicsMicroarray gene expression profiling of kinase-dependent and kinase-independent effects of GRK2
The ubiquitously expressed G-protein-coupled receptor kinase 2 (GRK2, ADRBK1) is an indispensable kinase involved in growth, differentiation and development. Exaggerated GRK2 activity plays a major pathophysiological role in the development of cardiovascular diseases such as heart failure and hypert...
ORGANISM(S): Homo sapiens 
2012-12-06 | E-GEOD-42771 | biostudies-arrayexpress
TranscriptomicsGRK2 deficiency confers cardioprotective profile.
This SuperSeries is composed of the following subset Series: GSE41706: Expression data from adult (9 month-old) hearts from GRK2 heterozygous C57BL/6J mice and its wild type littermates GSE41807: Expression data from adult (9 month-old) and young (4 month-old) hearts from C57BL/6J mice GSE41808: Exp...
ORGANISM(S): Mus musculus 
2012-10-25 | E-GEOD-41810 | biostudies-arrayexpress
ProteomicsGRK2 influences the phosphorylation of PER proteins by LC-MS/MS
To test whether GRK2 influences the phosphorylation of PER proteins, we used mass spectrometry to identify residues in V5-tagged murine PER2 that may be differentially phosphorylated upon GRK2 overexpression in Neuro2A cells.
ORGANISM(S): Mus musculus (Mouse) 
2015-07-22 | PXD002290 | Pride
Neuro2a cells In-gel digestion Lc-ms/ms 
TranscriptomicsExpression data from adult (9 month-old) and young (4 month-old) hearts from GRK2 heterozygous C57BL/6J mice.
G protein-coupled receptor kinase 2 (GRK2) has emerged as a key regulator of cardiac function and myocardial structure. Cardiac GRK2 is increased in heart failure and ischemia in humans, whereas genetic inhibition of GRK2 is cardioprotective in animal models of these pathologies. However, the mechan...
ORGANISM(S): Mus musculus 
2012-10-25 | E-GEOD-41808 | biostudies-arrayexpress
TranscriptomicsExpression data from adult (9 month-old) hearts from GRK2 heterozygous C57BL/6J mice and its wild type littermates
G protein-coupled receptor kinase 2 (GRK2) has emerged as a key regulator of cardiac function and myocardial structure. Cardiac GRK2 is increased in heart failure and ischemia in humans, whereas genetic inhibition of GRK2 is cardioprotective in animal models of these pathologies. However, the mechan...
ORGANISM(S): Mus musculus 
2012-10-20 | E-GEOD-41706 | biostudies-arrayexpress
TranscriptomicsExpression data from young (4 month-old) hearts from GRK2 heterozygous C57BL/6J mice and its wild type littermates
G protein-coupled receptor kinase 2 (GRK2) has emerged as a key regulator of cardiac function and myocardial structure. Cardiac GRK2 is increased in heart failure and ischemia in humans, whereas genetic inhibition of GRK2 is cardioprotective in animal models of these pathologies. However, the mechan...
ORGANISM(S): Mus musculus 
2012-10-25 | E-GEOD-41809 | biostudies-arrayexpress
GenomicsCardiac transcriptome analysis of RKIP-transgenic and GRK2-transgenic mice by NGS
Cardiac transcriptome analysis of RKIP-transgenic and GRK2-transgenic mice by NGS
PRJNA790970 | ENA
TranscriptomicsCardiac transcriptome analysis of RKIP-transgenic and GRK2-transgenic mice by NGS
The RAF kinase inhibitor protein, RKIP, is a dual inhibitor of the RAF1 kinase and the G-protein-coupled receptor kinase 2 (GRK2). By inhibition of the proto-oncogenic and pro-survival RAF1-MAPK pathway, the RAF kinase inhibitor protein, RKIP, acts as a tumor suppressor, which enhances cardiomyocyte...
ORGANISM(S): Mus musculus 
2021-12-27 | GSE191316 | GEO
GenomicsThe G-Protein-Coupled Receptor Kinase 2 (GRK2) Orchestrates Hair Follicle Homeostasis
The G-Protein-Coupled Receptor Kinase 2 (GRK2) Orchestrates Hair Follicle Homeostasis
PRJNA1089159 | ENA
TranscriptomicsMicroarray gene expression profiling of kinase-dependent and kinase-independent effects of GRK2
The ubiquitously expressed G-protein-coupled receptor kinase 2 (GRK2, ADRBK1) is an indispensable kinase involved in growth, differentiation and development. Exaggerated GRK2 activity plays a major pathophysiological role in the development of cardiovascular diseases such as heart failure and hypert...
ORGANISM(S): Homo sapiens 
2012-12-06 | GSE42771 | GEO
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