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TranscriptomicsBiological Similarities Exist between Oligoarticular and Polyarticular Subtypes of JIA Based on Age at Onset
Objective. To identify gene expression differences in peripheral blood from patients with early and late onset juvenile idiopathic arthritis (JIA). Methods. Peripheral blood mononuclear cells (PBMC) were isolated from 56 healthy controls and 104 patients with recent onset JIA (39 persistent oligo...
ORGANISM(S): Homo sapiens 
2011-02-14 | E-GEOD-20307 | biostudies-arrayexpress
TranscriptomicsExpression Signatures in Polyarticular JIA Show Heterogeneity and Offer a Molecular Classification of Disease Subsets
Objective. Microarray analysis was used to determine whether children with recent onset polyarticular juvenile idiopathic arthritis (JIA) exhibit biologically or clinically informative gene expression signatures in peripheral blood mononuclear cells (PBMC). Methods. Peripheral blood samples were o...
ORGANISM(S): Homo sapiens 
2009-06-30 | E-GEOD-13849 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiling in Peripheral Blood in Untreated New Onset Systemic Juvenile Idiopathic Arthritis
Systemic Juvenile Idiopathic Arthritis (sJIA) has been strongly associated with macrophage activation syndrome (MAS). To better understand the pathogenesid of sJIA and to facilitate the search for MAS biomarkers, we examine gene expression profiles in untreated new onset sJIA. 17 new onset sJIA pat...
ORGANISM(S): Homo sapiens 
2007-11-01 | E-GEOD-7753 | biostudies-arrayexpress
TranscriptomicsSerum Follistatin-Like Protein 1 Is a Biomarker for Macrophage Activation Syndrome and May Predict Disease Course in Systemic Juvenile Idiopathic Arthritis
Objective. Follistatin-like protein 1 (FSTL-1) is a secreted glycoprotein that is over-expressed in certain inflammatory diseases. Our objective in this study was to correlate FSTL-1 levels with measures of clinical disease activity in systemic juvenile idiopathic arthritis (sJIA), including macrop...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-GEOD-38849 | biostudies-arrayexpress
TranscriptomicsImmature cell populations and an erythropoiesis gene expression signature in systemic juvenile idiopathic arthritis: Implications for pathogenesis
Objective. Previous observations suggest that active systemic juvenile idiopathic arthritis (sJIA) is associated with a prominent erythropoiesis gene expression signature. The aim of this study was to determine the association of this signature with peripheral blood mononuclear cell (PBMC) subpopula...
ORGANISM(S): Homo sapiens 
2010-07-30 | E-GEOD-21521 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiling of Peripheral Blood Mononuclear Cells from Children With Active Hemophagocytic Lymphohistiocytosis
Familial hemophagocytic lymphohistiocytosis (FHL) is a rare, genetically heterogeneous autosomal recessive immune disorder that results when the critical regulatory pathways that mediate immune defense mechanisms and the natural termination of immune/inflammatory responses are disrupted or overwhelm...
ORGANISM(S): Homo sapiens 
2011-12-12 | E-GEOD-26050 | biostudies-arrayexpress
TranscriptomicsGene expression data of whole blood of systemic juvenile idiopathic arthritis (SJIA) patients treated with canakinumab or placebo and age matched healthy controls
Canakinumab is a human anti-interleukin-1 beta (IL-1 beta) monoclonal antibody neutralizing IL-1 beta. Systemic juvenile idiopathic arthritis (SJIA) is a rare, multigenic, autoinflammatory disease of unknown etiology characterized by chronic arthritis; intermittent high-spiking fever, rash, and elev...
ORGANISM(S): Homo sapiens 
2016-04-29 | E-GEOD-80060 | biostudies-arrayexpress
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