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TranscriptomicsHepatocyte ductal metaplasia in chronic mouse liver injury
Expression profiling of hepatocytes-derived ductal cells with properties intermediate between mature hepatocytes and cholangiocytes. Chimeric adult mice were generated where mature hepatocytes were marked with a fluorescent red marker. Chronic injury was induced for ~6weeks and three cell types wer...
ORGANISM(S): Mus musculus 
2014-09-01 | E-GEOD-55552 | biostudies-arrayexpress
TranscriptomicsHuman hepatocyte metaplasia in injured humanized mouse livers
The goal of this experiment was to test whether human hepatocytes could give rise to biliary-like progenitor cells in an in vivo context. Here Fah-/- Il2ry-/- Rag2-/-NOD mouse livers were humanized with human hepatocytes. Only hepatocytes engraft in the Fah-/- mouse at detectable levels in this mod...
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-58679 | biostudies-arrayexpress
TranscriptomicsOxymetholone therapy of Fanconi anemia suppresses osteopontin transcription and induces hematopoietic stem cell cycling
We used Fancd2-/- mice to understand its mechanism of action. Transcriptome analysis of cKit+ Sca1+ Lin- (KSL) cells discovered that only four genes changed their expression levels significantly after chronic OXM administration in both Fancd2−/− and wild-type mice: mKi67 and Cenpf were up-regualted ...
ORGANISM(S): Mus musculus 
2015-01-06 | E-GEOD-58724 | biostudies-arrayexpress
TranscriptomicsMolecular mechanism behind the hematopoiesis-enhancing effect of SRT3025
We used wild-type 129 mice to understand the mechanism of action behind SRT3025’s hematopoiesis-enhancing effect. Transcriptome analysis of cKit+ Sca1+ Lin- cells (KSL) cells discovered that a list of genes changed their expression levels significantly after SRT3025 administration in wild-type mice....
ORGANISM(S): Mus musculus 
2015-07-04 | E-GEOD-60941 | biostudies-arrayexpress
TranscriptomicsDifferential expression of sorted Alpha and Beta cells
The goal of this experiment is to identify genes differentially expressed in FACS-sorted Alpha and Beta cells.
ORGANISM(S): Homo sapiens 
2011-07-23 | E-MTAB-465 | biostudies-arrayexpress
TranscriptomicsDifferential expression of representative sorted pancreatic cells
The goal of this experiment is to identify genes differentially expressed in representative pancreatic FACS-sorted cell types.
ORGANISM(S): Homo sapiens 
2011-07-26 | E-MTAB-463 | biostudies-arrayexpress
TranscriptomicsmicroRNAseq of primary human gallbladder cells, reprogrammed human gallbladder cells, and human pancreatic beta cells
We determined the global microRNA expression profiles of primary human gallbladder cells and genetically reprogrammed human gallbladder cells and compared with pancreatic beta cells to ascertain the degree of cellular transdifferentatiation of insulin-producing human gallbladder cells to become beta...
ORGANISM(S): Homo sapiens 
2017-08-02 | E-MTAB-5554 | biostudies-arrayexpress
TranscriptomicsCell surface markers that distinguish human beta cells and alpha cells
The goal of this experiment is to determine cell surface markers that are present in human beta cells or alpha cells but not both. Cells from human islets were FACS sorted and prepared as matched pairs of beta and alpha cells preparations.
ORGANISM(S): Homo sapiens 
2011-06-10 | E-MTAB-459 | biostudies-arrayexpress
TranscriptomicsBaseline gene expression profile of human extrahepatic biliary cells/biliospheres in vitro
Aim: To determine the baseline gene expression profile of human gallbladder and cystic duct cells at various stages from isolation in fresh biopsy samples to early and later passages in culture.
ORGANISM(S): Homo sapiens 
2015-03-31 | E-MTAB-3456 | biostudies-arrayexpress
TranscriptomicsFoxl1-Cre-marked Adult Hepatic Progenitors Have Clonogenic and Bi-Lineage Differentiation Potential - Time Course
The winged helix transcription factor Foxl1 is a marker for progenitor cells and their descendants in the mouse liver in vivo. Here, we purify progenitor cells from Foxl1-Cre; RosaYFP mice and evaluate their proliferative and differentiation potential in vitro. Treatment of Foxl1-Cre; RosaYFP mice w...
ORGANISM(S): Mus musculus 
2011-05-01 | E-GEOD-28890 | biostudies-arrayexpress
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