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GenomicsTranscription factor Ebf1 regulates differentiation stage-specific signaling, proliferative expansion and survival of B cells [H3K4me2 and H3K4me3]
Transcription factor Ebf1 is an important determinant of early B lymphopoiesis. To gain insight into differentiation stage-specific functions of Ebf1, we conditionally inactivated Ebf1. We found that Ebf1 is required for proliferation, survival and signaling of pro-B cells and peripheral B cell su...
ORGANISM(S): Mus musculus 
2012-04-02 | E-GEOD-35914 | biostudies-arrayexpress
GenomicsTranscription factor Ebf1 regulates differentiation stage-specific signaling, proliferative expansion and survival of B cells [EBF1]
Transcription factor Ebf1 is an important determinant of early B lymphopoiesis. To gain insight into differentiation stage-specific functions of Ebf1, we conditionally inactivated Ebf1. We found that Ebf1 is required for proliferation, survival and signaling of pro-B cells and peripheral B cell su...
ORGANISM(S): Mus musculus 
2012-04-02 | E-GEOD-35910 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis to identify genes that are differentially expressed in resting and in LPS-activated splenic B cells of Ebf1+/fl-RERTCre and Ebf1fl/fl-RERTCre mice
Using resting and LPS-stimulated B cells from mice carrying two Ebf1 alleles flanked with loxP sites and an inducible Cre recombinase, target genes of Ebf 1 and the effect of Ebf1 deletion on the cells was analyzed. Target genes of Ebf 1 and the effect of Ebf1 deletion on the cells was analyzed. Ebf...
ORGANISM(S): Mus musculus 
2012-04-02 | E-GEOD-36061 | biostudies-arrayexpress
TranscriptomicsEbf1 ChIP
Ebf1 is a key determinant of B-lymphocyte specification. In order to identify unknown transcriptional targets, endogenous Ebf1 was isolated by chromatin-IP from primary pro-B cells and the copurified DNA was hybridized to promoter tiling arrays. Ebf1 was ChIPed using a polyclonal antibody directed a...
ORGANISM(S): Mus musculus 
2010-06-24 | E-GEOD-21469 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of fetal liver pro-B cells upon deletion of Early B-cell Factor 1 (Ebf1)
Using cultured pro-B cells from mice carrying two Ebf1 alleles flanked with loxP sites and an inducible Cre recombinase, target genes of Ebf 1 and the effect of Ebf1 deletion on the cells was analyzed Ebf1 fl/fl pro-B cells and heterozygote control cells were treated with 4-hydroxy-tamoxifen (4OHT) ...
ORGANISM(S): Mus musculus 
2010-07-29 | E-GEOD-21454 | biostudies-arrayexpress
TranscriptomicsGene expression analysis after reconstitution of Ebf1-deficient pre-pro-B cells with Ebf1
Ebf1 deficient pre-pro B-cells (Fraction A) can be cultured in the presence of stromal feeders and cytokines. The retroviral transduction of these cells with Ebf1 was used as gain-of-function experiment for the analysis of direct and functional target genes of Ebf1. Ebf1 deficient pre-pro B-cells we...
ORGANISM(S): Mus musculus 
2010-07-29 | E-GEOD-21455 | biostudies-arrayexpress
TranscriptomicsEarly B Cell Factor 2 Regulates Hematopoietic Stem Cell Homeostasis in a Cell-Nonautonomous Manner
Hematopoiesis requires the interaction of hematopoietic stem cells (HSCs) with various stromal microenvironments. Here, we examine the role of early B cell factor 2 (Ebf2), a transcription factor expressed in a subset of immature osteoblastic cells. Ebf2-/- mice show decreased frequencies of HSCs an...
ORGANISM(S): Mus musculus 
2011-04-26 | E-GEOD-21700 | biostudies-arrayexpress
UnknownThe CCR4-NOT complex contributes to repression of Major Histocompatibility Complex class II transcription.
Not available
S-EPMC5471237 | biostudies-literature
TranscriptomicsExpression data from long-term Ebf1-deficient, CD19+, Bcl2tg cells
An assessment of a role of Ebf1 in committed B lineage cells. In this study, we adopted the strategy of deleting Ebf1 after reconstitution of Rag2-/-Il2rg-/- mice and found that committed pre-B cells could be converted into T cells and ILCs upon deletion of Ebf1. We used µ-arrays to gain insight int...
ORGANISM(S): Mus musculus 
2013-06-01 | E-GEOD-46349 | biostudies-arrayexpress
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