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TranscriptomicsRNA-seq of the brain of Nothobranchius furzeri at different time points
Background: Comparison of temporal gene expression profiles (www.jenage.de) The RNA-seq data comprises 5 age groups: 5,12,20,27,39 weeks 25 samples: 5 biological replicates for each age group
ORGANISM(S): Nothobranchius furzeri 
2014-07-29 | E-GEOD-52462 | biostudies-arrayexpress
TranscriptomicsImpaired Insulin-/IGF1-Signaling Extends Life Span by Promoting Mitochondrial L-Proline Catabolism to Induce a Transient ROS-Signal
Transcriptome profiling of three models with impaired insulin/IGF1 signaling. 1. Deep sequencing of endogenous mRNA from Caenorhabditis elegans N2 var. Bristol (wildtype) and daf-2(e1370) mutant; 2. Deep sequencing of endogenous mRNA from murine embryonic fibroblasts (MEF) wildtype and irs1-/- kno...
ORGANISM(S): Caenorhabditis elegans 
2012-02-25 | E-GEOD-36041 | biostudies-arrayexpress
TranscriptomicsDeeply conserved gene-regulatory functions of carboxy-terminal domains in dictyostelid C-module-binding factors
We describe the gene expression pattern of a Dictyostelium discoideum mutant depleted in the C-module-binding factor (CbfA) and autonomous gene-regulatory activities of CbfA carboxy-terminal domains (CbfA-CTDs) Comparison of gene expression in growing cells of a CbfA mutant compared to wild-type
ORGANISM(S): Dictyostelium discoideum 
2012-06-03 | E-GEOD-38418 | biostudies-arrayexpress
TranscriptomicsDeep sequencing of endogenous mRNA from Caenorhabditis elegans in the presence and absence of arsenite
Background: Arsenite is one of the most toxic chemical substances known and is assumed to exert detrimental effects on viability even at lowest concentrations. By contrast and unlike higher concentrations, we here find that exposure to low-dose arsenite promotes growth of cultured mammalian cells. I...
ORGANISM(S): Caenorhabditis elegans 
2013-04-23 | E-GEOD-46257 | biostudies-arrayexpress
TranscriptomicsDeep sequencing of endogenous mRNA from Caenorhabditis elegans in the presence and absence of rotenone at 4 different time points
Background: We here show that inhibitors of mitochondrial complex I promote physical activity, stress resistance as well as lifespan of Caenorhabditis elegans despite normal food uptake, i.e. in the absence of DR. Dietary restriction (DR) extends lifespan and promotes metabolic health in evolutionar...
ORGANISM(S): Caenorhabditis elegans 
2013-04-16 | E-GEOD-46051 | biostudies-arrayexpress
TranscriptomicsDeep sequencing of endogenous mRNA from Caenorhabditis elegans in the presence and absence of 1-methylnicotinamide (MNA) and nicotinic acid (NA)
Sirtuins, a family of histone deacetylases, have a fiercely debated role in regulating lifespan of different species. Contrasting recent observations, we here find that overexpression of sir-2.1, the orthologue of mammalian SirT1, does extend C. elegans lifespan. Sirtuins are known to convert NAD+ i...
ORGANISM(S): Caenorhabditis elegans 
2013-08-09 | E-GEOD-49662 | biostudies-arrayexpress
TranscriptomicsRNA-seq of C.elegans and M.musculus in the presence and absence of D-Glucosamine (GlcN)
D-Glucosamine (2-amino-2-deoxy-D-glucose, C.A.S.# 3416-24-8) (GlcN) is a freely available and commonly used dietary supplement possibly promoting cartilage health in humans which also acts as an inhibitor of glycolysis. We here find that GlcN extends C. elegans lifespan by impairing glucose metaboli...
ORGANISM(S): Mus musculus 
2014-03-07 | E-GEOD-54853 | biostudies-arrayexpress
TranscriptomicsRNA-seq of young and quiescent MRC-5 human fibroblasts
Quiescent MRC-5 fibroblasts were compared to young fibroblasts 6 samples: 3 biological replicates for each age group: young and quiescent MRC-5 cells. 50bp, single-end reads, no strand-specific reads
ORGANISM(S): Homo sapiens 
2014-11-06 | E-GEOD-60883 | biostudies-arrayexpress
TranscriptomicsDeep sequencing of endogenous mRNA from Caenorhabditis elegans in the presence of 2-deoxy-D-glucose (DOG) at 4 different time points
Background: C. elegans fed with a chemical inhibitor of glucose, namely 2-deoxy-D-glucose (DOG), exhibit considerably extended life span. DOG, in contradiction to D-glucose, cannot be metabolized in the glycolytic pathway. This results in the fact that less glucose is available for ATP production, a...
ORGANISM(S): Caenorhabditis elegans 
2013-11-06 | E-GEOD-46344 | biostudies-arrayexpress
UnknownBlood culture practices and microbiological capacity for sepsis diagnostics in Europe (2021-2022): a cross-sectional analysis of the European Sepsis Care Survey.
Not available
S-EPMC12771334 | biostudies-literature
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