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TranscriptomicsMolecular basis for chromatin binding and regulation of MLL5
The human mixed lineage leukemia 5 (MLL5) protein mediates hematopoietic cell homeostasis, cell cycle and survival, however, the molecular basis underlying MLL5 activities remains unknown. Here, we show that MLL5 is recruited to gene-rich euchromatic regions via the interaction of its PHD finger wit...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-47100 | biostudies-arrayexpress
GenomicsThe nucleosomal barrier to promoter escape by RNA Polymerase II is overcome by the chromatin remodeler Chd1 [HiSeq]
We use a metabolic labeling strategy for directly measuring nucleosome turnover to determine the role of chromatin remodeler Chd1 on chromatin dynamics in mouse embryonic fibroblasts expressing with wildtype-Chd1 and dominant negative K510R-Chd1. We find that expression of K5 10R-Chd1 decreases nucl...
ORGANISM(S): Mus musculus 
2014-04-15 | E-GEOD-52501 | biostudies-arrayexpress
UnknownBivalent domains enforce transcriptional memory of DNA methylated genes in cancer cells.
Not available
S-EPMC2596747 | biostudies-literature
GenomicsDistinct activities of Myf5 and MyoD indicate sequential roles in skeletal muscle lineage specification and differentiation (ChIP-Seq)
In this work we compare the molecular functions of Myf5 and MyoD, two highly related bHLH transcription factors that regulate skeletal muscle specification and differentiation. We find MyoD and Myf5 bind the same sites genome-wide but have distinct functions: Myf5 induces histone acetylation without...
ORGANISM(S): Mus musculus 
2016-03-01 | E-GEOD-75370 | biostudies-arrayexpress
UnknownCalcium influx rapidly establishes distinct spatial recruitments of Annexins to cell wounds.
Not available
S-EPMC11304956 | biostudies-literature
UnknownH3 K79 dimethylation marks developmental activation of the beta-globin gene but is reduced upon LCR-mediated high-level transcription.
Not available
S-EPMC2442750 | biostudies-literature
UnknownMolecular basis for chromatin binding and regulation of MLL5.
Not available
S-EPMC3710826 | biostudies-literature
UnknownAn acetyl-methyl switch drives a conformational change in p53.
Not available
S-EPMC4317571 | biostudies-literature
UnknownThe histone-H3K4-specific demethylase KDM5B binds to its substrate and product through distinct PHD fingers.
Not available
S-EPMC3918441 | biostudies-literature
TranscriptomicsDistinct activities of Myf5 and MyoD indicate sequential roles in skeletal muscle lineage specification and differentiation (RNA-Seq)
In this work we compare the molecular functions of Myf5 and MyoD, two highly related bHLH transcription factors that regulate skeletal muscle specification and differentiation. We find MyoD and Myf5 bind the same sites genome-wide but have distinct functions: Myf5 induces histone acetylation without...
ORGANISM(S): Mus musculus 
2016-03-01 | E-GEOD-75631 | biostudies-arrayexpress
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