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MetabolomicsX-ray Irradiation Suppresses Keloid Growth by Inducing G2/M Arrest via the Phytosphingosine-KIF20A Axis
Keloid radiotherapy is clinically effective but has an incomplete underlying molecular mechanism and limited accessibility; we used X-ray exposure to identify effector pathways replicating its antifibrotic benefits without further radiation. After collecting patient keloid samples, primary human kel...
2026-06-06 | MTBLS14461 | MetaboLights
TranscriptomicsHigh-resolution genome-wide transcriptomics analysis of O. dioica during recovery from growth arrest
Polycistronic mRNAs transcribed from operons are resolved via the trans-splicing of a spliced leader (SL) RNA. The SL is also frequently trans-spliced to monocistronic transcripts. Using a modified cap analysis of gene expression (CAGE) protocol we mapped sites of SL trans-splicing genome-wide in th...
ORGANISM(S): Oikopleura dioica 
2015-01-26 | E-GEOD-50848 | biostudies-arrayexpress
TranscriptomicsType-1-cytokines synergize with oncogene inhibition to induce tumor growth arrest
Both targeted inhibition of oncogenic driver mutations and immune-based therapies show efficacy in treatment of patients with metastatic cancer but responses are either short-lived or incompletely effective. Oncogene inhibition can augment the efficacy of immune-based therapy but mechanisms by which...
ORGANISM(S): Mus musculus 
2015-02-20 | E-GEOD-62249 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human T98G during asynchronous growth or under growth arrest by serum deprivation or contact inhibition
Triplicate experiments from T98G cells under asynchronously growing, and growth arrest by serum deprivation and contact inhibition.
ORGANISM(S): Homo sapiens 
2007-11-06 | E-GEOD-1692 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat astrocyte cell line RCG-12 to investigate cell growth arrest and differentiation
We performed global scale microarray analysis to identify detailed mechanisms by which nonpermissive temperature induces cell growth arrest and differentiation in astrocyte RCG-12 cells harboring temperature-sensitive simian virus 40 large T-antigen by using an Affymetrix GeneChip system. Astrocyte ...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-7501 | biostudies-arrayexpress
GenomicsRNA-seq of e.coli under growth, regulated growth arrest and disrupted growth arrests - second repetition
RNA-seq of e.coli under growth, regulated growth arrest and disrupted growth arrests - second repetition
PRJEB78730 | ENA
ProteomicsThe lncRNA Growth Arrest Specific 5 regulates cell survival via distinct structural modules with independent functions
There is increasing evidence that the architecture of long non-coding RNAs – just like that of proteins – is hierarchically organized into independently folding sub-modules with distinct functions. Studies characterizing the cellular activities of such modules, however, are rare. The lncRNA growth a...
ORGANISM(S): Homo sapiens (Human) 
2021-04-07 | PXD018584 | Pride
Proteomics Non-coding rna Growth arrest 
ProteomicsA proteomic study of bacterial growth arrest in a synthetic biology application
Scaling up the functioning of synthetic circuits from microplates to bioreactors is far from trivial to achieve. We here test the scalability performance of a previously developed growth switch for increasing product yields in bacteria, based on external control of RNA polymerase expression. We show...
ORGANISM(S): Escherichia coli 
2021-11-25 | PXD024231 | Pride
Metabolic engineering Growth switch Escherichia coli Nanolc-ms/ms 
GenomicsChIP-Seq of RNA Pol II with antibodies S2, 4H8 and 8WG16 during C. elegans L1 arrest and recovery
When C. elegans larvae hatch in the absence of food they persist in a stress resistant, developmentally arrested state (L1 arrest) for weeks or until food becomes available. We characterized growth, mRNA expression, and RNA Polymerase II activity genome-wide during L1 arrest and recovery. RNA Pol ...
ORGANISM(S): Caenorhabditis elegans 
2009-02-27 | E-GEOD-13973 | biostudies-arrayexpress
TranscriptomicsCirculating microRNAs to predict neurological outcome after sudden cardiac arrest
Studies of miRNA profiling to predict outcome in cardiac arrest patients treated with therapeutic hypothermia (TH) Venous blood was collected in citrated tubes prior discharge. Plasma was harvested by centrifugation and stored at -80°C until assayed. Identical volumes of plasma from the 14 patients...
ORGANISM(S): Homo sapiens 
2013-01-11 | E-GEOD-34643 | biostudies-arrayexpress
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