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TranscriptomicsEpigenetic silencing of Th1 chemokines shapes tumor immunity, immunotherapy and patient outcome [GSK126]
To define the gene profile altered by EZH2 and H3K27me3 in response to IFNg, we performed several microarrays in primary ovarian cancer cells transfected with shEZH2 or treated with GSK126. We found that 155 and 124 genes were altered by shEZH2 and GSK126 treatment, respectively, and 20 genes were i...
ORGANISM(S): Homo sapiens 
2015-08-11 | E-GEOD-71869 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of EZH2 mutant and wild type DLBCL cell lines treated with EZH2 inhibitor
We studied transcriptional changes by Affymetrix human microarrays in DLBCL cell lines as a result of treatment with GSK126, a potent, highly-selective, SAM-competitive, small molecule inhibitor of EZH2 In eukaryotes, epigenetic post-translational modification of histones is critical for regulation ...
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-40971 | biostudies-arrayexpress
TranscriptomicsCUT&Tag of H3K27Ac of HCT26-1T: Control and GSK126
CUT&Tag for H3K27Ac; Colorectal cancer patient derived organoids, HCT26-1T; drug experiment of control vs GSK126.
ORGANISM(S): Homo sapiens 
2025-11-20 | E-MTAB-16203 | biostudies-arrayexpress
GenomicsExpression analysis after co-treatment of GSK126 and pomalidomide
Expression analysis after co-treatment of GSK126 and pomalidomide
PRJNA613728 | ENA
GenomicsBMP2 and GSK126 synergize to induce expression of osteogenic genes
BMP2 and GSK126 synergize to induce expression of osteogenic genes
PRJNA560888 | ENA
GenomicsCUT&Tag of H3K27Ac of HCT26-1T: Control and GSK126
CUT&Tag of H3K27Ac of HCT26-1T: Control and GSK126
PRJEB104027 | ENA
UnknownBlocking EZH2 methylation transferase activity by GSK126 decreases stem cell-like myeloma cells.
Not available
S-EPMC5356890 | biostudies-literature
GenomicsEZH2 inhibitor GSK126 promotes human iPSC hematopoietic differentiation
EZH2 inhibitor GSK126 promotes human iPSC hematopoietic differentiation
PRJNA1508807 | ENA
GenomicsEffects on gene expression of lapatinib and/or GSK126 treatment in SKBR3 cells
Effects on gene expression of lapatinib and/or GSK126 treatment in SKBR3 cells
PRJNA1299364 | ENA
TranscriptomicsExpression analysis after co-treatment of GSK126 and pomalidomide
To determine combination effect of GSK126 and pomalidomide at the RNA levels in EZH2 Y641 mutant DLBCL, We performed gene expression profiling in WSU-DLCL2 cell line after co-treatment of GSK126 and pomalidomide
ORGANISM(S): Homo sapiens 
2020-09-23 | GSE147320 | GEO
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