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TranscriptomicsGSK3B shRNA in Panc-1 xenografts
The Panc-1 human pancreatic cancer line (ATCC) was constructed to stably express control or GSK3B shRNA. Control or GSK3B shRNA expressing Panc-1 cells were implanted subcutaneously into the flanks of 3-5 week old, female, athymic nude mice. Tumors were grown to at least 250mm3. Tumor tissue was mic...
ORGANISM(S): Homo sapiens 
2014-01-09 | E-GEOD-35351 | biostudies-arrayexpress
GenomicsTranscriptome change led by GSK3B knockout (KO) in colon cancer RKO cells
Transcriptome change led by GSK3B knockout (KO) in colon cancer RKO cells
PRJNA1473257 | ENA
GenomicsImpact of GSK3B on accessible chromatin regions in colon cancer RKO cells
Impact of GSK3B on accessible chromatin regions in colon cancer RKO cells
PRJNA1473256 | ENA
GenomicsImpact of GSK3B on genome-wide H3K27ac in colon cancer RKO cells
Impact of GSK3B on genome-wide H3K27ac in colon cancer RKO cells
PRJNA1473259 | ENA
ProteomicsRas-MAPK inhibition induces AXIN1 loss in colorectal cancer by mTOR associated suppression of protein synthesis.
In this study, we deciphered cellular mechanisms underlying AXIN1 loss by MEK1/2 inhibition in colorectal cancer (CRC). We observed that both MEK1/2 and GSK3B inhibitors strongly reduce AXIN1 levels across multiple CRC models. Inhibition of MEK1/2, but not GSK3B, causes a reduction of AXIN1 transcri...
ORGANISM(S): Homo sapiens (Human) 
2026-06-03 | PXD067308 | Pride
Gsk3b inhibition Mek inhibition Hct116 Immunoprecipitation Lc-ms/ms Colorectal cancer 
TranscriptomicsGSK3B shRNA in Panc-1 xenografts
The Panc-1 human pancreatic cancer line (ATCC) was constructed to stably express control or GSK3B shRNA. Control or GSK3B shRNA expressing Panc-1 cells were implanted subcutaneously into the flanks of 3-5 week old, female, athymic nude mice. Tumors were grown to at least 250mm3. Tumor tissue was mic...
ORGANISM(S): Homo sapiens 
2014-01-09 | GSE35351 | GEO
UnknownGSK3B induces autophagy by phosphorylating ULK1.
Not available
S-EPMC8080724 | biostudies-literature
GenomicsThe effect of Intestinal epithelial GSK3B loss on chromatin accessibility in the AOM/DSS-induced colon cancer model
The effect of Intestinal epithelial GSK3B loss on chromatin accessibility in the AOM/DSS-induced colon cancer model
PRJNA1473260 | ENA
ProteomicsBRAF/MAPK and GSK3b signalling signaling converge to control MITF nuclear export
The close integration of the MAPK, PI3K and WNT signaling pathways underpins much of development and is deregulated in cancer. In principle, combinatorial post-translational modification of key lineage–specific transcription factors would be an effective means to integrate critical signaling events....
ORGANISM(S): Mus musculus (Mouse) 
2022-02-28 | PXD010665 | Pride
Mitf | melanoma | mapk | nuclear export | gsk3b 
UnknownMicroRNA-214-3p facilitates M2 macrophage polarization by targeting GSK3B.
Not available
S-EPMC11896522 | biostudies-literature
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