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In animals, egg activation triggers a cascade of posttranscriptional events that act on maternally synthesized RNAs. We show that, in Drosophila, the PAN GU (PNG) kinase sits near the top of this cascade, triggering translation of SMAUG (SMG), a multifunctional posttranscriptional regulator conserve...
ORGANISM(S): Drosophila melanogaster 
dsRNA-mediated gene silencing (RNAi) can be inherited for multiple generations in C. elegans. To understand this process we conducted a genetic screen for animals defective for transmitting RNAi silencing signals to future generations. This screen identified the gene heritable RNAi defective (hrde)-...
ORGANISM(S): Caenorhabditis elegans 
Thermal proteome profiling data for SW480 colon cancer cells treated with either the ALDH1B1 inhibitor IGUANA-1 or DMSO vehicle alone.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-02-11 | MSV000088824 | MassIVE
Current therapies for medulloblastoma (MB), a highly malignant childhood brain tumor, impose debilitating effects on the developing child, warranting the development of molecularly targeted treatments with reduced toxicities. Prior studies have failed to disclose the full spectrum of driver genes an...
WGS data of medulloblastoma tumor/control pairs.
WGS data of medulloblastoma tumor/control pairs.
WGS data of medulloblastoma tumor/control pairs.
Exome sequencing data for medulloblastoma tumor/control pairs
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