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TranscriptomicsSlicing-Independent RISC Activation Requires the Argonaute PAZ Domain
Small RNAs regulate the genetic networks through a ribonucleoprotein complex called the RNA induced silencing complexes (RISC), which in mammals contains at its center one of four Argonaute proteins (Ago1-4). A key regulatory event in the RNAi and miRNA pathways is Ago loading, where double stranded...
ORGANISM(S): Homo sapiens 
2012-07-12 | E-GEOD-39146 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression profiling of mouse liver tissue samples after treated with various anti-HCV shRNAs
RNA interference (RNAi) is becoming routine in scientific discovery and treating human disease. However, its applications are hampered by unwanted effects. The RNA-Seq analyses from mouse liver samples expressing various anti-HCV shRNAs show that weak base-pairing in both seed and 3’ regions is requ...
ORGANISM(S): Mus musculus 
2014-10-03 | E-GEOD-55131 | biostudies-arrayexpress
UnknownIntegrating network pharmacology and experimental validation to uncover the synergistic effects of Huangqi ()-Ezhu () with 5-fluorouracil in colorectal cancer models.
Not available
S-EPMC11955770 | biostudies-literature
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