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TranscriptomicsHigh Fat Diet Triggers SIRT1 Cleavage in Adipose Tissue Providing a Link between Dietary Stress and Metabolic Dysfunction.
Adipose tissue plays an important role in storing excess nutrients and preventing ectopic lipid accumulation in other organs. Obesity leads to excess lipid storage in adipocytes, resulting in the generation of stress signals and the derangement of metabolic functions. SIRT1 is an important regulator...
ORGANISM(S): Mus musculus 
2012-12-21 | E-GEOD-30247 | biostudies-arrayexpress
TranscriptomicsSIRT1 impact on global gene expression in the brain
We compared expression of genes in brains of SIRT1 brain-specific knockouts (BSKO) to those of wild-type littermate controls (WT). RNA was isolated from whole brain tissues of SIRT1 brain specific knockout mice (BSKO) and their wild-type littermates (WT). 3 months old males were used, four biologica...
ORGANISM(S): Mus musculus 
2011-04-22 | E-GEOD-28790 | biostudies-arrayexpress
TranscriptomicsSIRT7 suppresses tumorigenesis by attenuating MYC activity
SIRT7 is a member of the mammalian sirtuin family of NAD+ dependent deacylases, and interacts with RNA polymerase I and UBF to regulate rDNA transcription. Various studies in mammalian cells and human clinical data have linked SIRT7 to cancer. However studies differ as to whether SIRT7 is oncogen...
ORGANISM(S): Mus musculus 
2014-08-20 | E-GEOD-50076 | biostudies-arrayexpress
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