Sort   by:  
 Page size 
TranscriptomicsHematopoietic stem cells progressively deficient of glycogen synthase kinase initiate a pre-neoplastic state required for evolution to acute leukemia
The cellular origin and molecular progression towards aggressive cancers such as acute myeloid leukemia (AML) remain elusive. Clinically, Myelodysplastic syndromes (MDS) and related myeloproliferative neoplasias (MPN) disorders1-5 are believed to present as a precursor stage to lethal AML developmen...
ORGANISM(S): Mus musculus 
2016-01-11 | E-GEOD-53352 | biostudies-arrayexpress
TranscriptomicsLocation of indigenous human HSCs reveals functional properties of HSCs that are dictated by anatomic and cellular architecture of bone marrow II
Demonstration of hematopoietic stem cells (HSCs) was first shown in the mouse and was dependent on recipient bone marrow (BM) to support in vivo multilineage hematopoietic reconstitution, thereby illustrating non-cell-autonomous requirements for HSC functions. Murine studies have defined microanatom...
ORGANISM(S): Mus musculus 
2013-08-01 | E-GEOD-47935 | biostudies-arrayexpress
TranscriptomicsLocation of indigenous human HSCs reveals functional properties of HSCs that are dictated by anatomic and cellular architecture of bone marrow I
Demonstration of hematopoietic stem cells (HSCs) was first shown in the mouse and was dependent on recipient bone marrow (BM) to support in vivo multilineage hematopoietic reconstitution, thereby illustrating non-cell-autonomous requirements for HSC functions. Murine studies have defined microanatom...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-47934 | biostudies-arrayexpress
Sort   by:  
 Page size