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GenomicsGenome-wide eNOS-DNA association in Prostate Cancer Cells
ChIP-Sequencing using antibody to eNOS in cells from a primary prostate cancer with poor outcome and metastatic LNCaP cells, in basal condition and after E2 treatment
ORGANISM(S): Homo sapiens 
2013-11-04 | E-MTAB-1204 | biostudies-arrayexpress
TranscriptomicsDeep Sequencing the microRNA profile in rhabdomyosarcoma reveals down-regulation of miR-378 family members
Rhabdomyosarcoma (RMS) is a highly malignant tumour accounting for nearly half of soft tissue sarcomas in children. Altered miRNA levels have been reported in human cancers, including RMS. Using deep sequencing technology, a total of 685 miRNAs were investigated in a group of alveolar RMSs (ARMSs), ...
ORGANISM(S): Homo sapiens 
2015-01-28 | E-MTAB-3246 | biostudies-arrayexpress
TranscriptomicsDeep-sequencing of endogenous microRNAs from human endothelial cells exposed to hypoxia and normoxia
Human Umbelical Vein Endothelial Cells (HUVEC) were cultured in vitro and exposed to 1% oxygen or normoxia for 24 hours. Then, small RNA libraries were prepared and sequenced using sequencing-by-ligation technique (Solid3 Plus Sequencer platform). Alignment versus miRBase v14.0 identified >400 diffe...
ORGANISM(S): Homo sapiens 
2012-02-07 | E-GEOD-26497 | biostudies-arrayexpress
TranscriptomicsBreast Cancer Initiating Cells RNA-seq
We previously reported the isolation and in vitro propagation of highly tumorigenic mammospheres (MCFS) isolated from MCF7 breast cancer cell line. In this study we obtained gene expression profiles of MCFS and parental MCF7 cell lines using SOLiD RNA-sequencing after linear isothermal DNA amplifica...
ORGANISM(S): Homo sapiens 
2015-11-13 | E-MTAB-2811 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of glioblastoma tissues and peritumoral regions by Serial Analysis of Gene Expression
In this study, we report a broad analysis of central tumor samples (C), from both Glioblastoma long term survivors (LT) and short term ones (ST), integrated by the same analysis performed on peritumoral areas (P) from the same patients. We provide data from SAGE analysis performed with deep sequenci...
ORGANISM(S): Homo sapiens 
2017-06-29 | E-MTAB-3258 | biostudies-arrayexpress
TranscriptomicsIdentification of Transcriptional markers in Peripheral Blood of Idiopathic PAH Patients
Pulmonary Arterial Hypertension (PAH) is characterized by progressive increase in pulmonary vascular resistance, right ventricular failure and premature death. Owing to severe complications, lung biopsies cannot be envisioned to characterize the disease. Based on the prominent role of inflammation i...
ORGANISM(S): Homo sapiens 
2020-01-18 | E-MTAB-3276 | biostudies-arrayexpress
TranscriptomicsMiRNome profiling of glioblastoma tissues and peritumoral regions
Glioblastoma multiforme (GBM) is the most common and deadliest primary brain tumor. Its prognosis is inexorably unfavorable, as these tumors drive affected patients to death usually within 15 months after diagnosis (short term survivors, ST), with the only exception of a small fraction of patients (...
ORGANISM(S): Homo sapiens 
2017-03-08 | E-MTAB-3239 | biostudies-arrayexpress
TranscriptomicsA platform of patient-derived tumor xenografts (EOC-xenografts) to recapitulate the clinicopathology and genetic alterations of ovarian cancer
Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy. On the basis of its histopathology and molecular-genomic changes ovarian cancer has been divided into subtypes, each with distinct biology and outcome. The aim of this study was to develop a panel of patient-derived EOC-xen...
ORGANISM(S): Homo sapiens 
2015-01-07 | E-GEOD-56920 | biostudies-arrayexpress
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