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TranscriptomicsAsymmetric cancer cell division regulated by AKT, Reactive Oxygen Species (ROS) high versus ROS low mRNA
Human tumors often contain slowly proliferating cancer cells that resist treatment but we do not know precisely how these cells arise. We show that rapidly proliferating cancer cells can divide asymmetrically to produce slowly proliferating “G0-like” progeny that are enriched following chemotherapy ...
ORGANISM(S): Homo sapiens 
2011-07-14 | E-GEOD-30465 | biostudies-arrayexpress
ProteomicsAKT Inhibition Promotes Non-autonomous Cancer Cell Survival [Antibody Arrays (L-507)]
Small-molecule inhibitors of AKT signaling are being in evaluated in patients with various cancer types, but have so far proven therapeutically disappointing for reasons that remain unclear. Here, we treat cancer cells with sub-therapeutic doses of Akti-1/2, an allosteric small molecule AKT inhibito...
ORGANISM(S): Homo sapiens 
2015-12-09 | E-GEOD-71892 | biostudies-arrayexpress
ProteomicsAKT Inhibition Promotes Non-autonomous Cancer Cell Survival [Antibody Arrays (L-493)]
Small-molecule inhibitors of AKT signaling are being in evaluated in patients with various cancer types, but have so far proven therapeutically disappointing for reasons that remain unclear. Here, we treat cancer cells with sub-therapeutic doses of Akti-1/2, an allosteric small molecule AKT inhibito...
ORGANISM(S): Homo sapiens 
2015-12-09 | E-GEOD-71891 | biostudies-arrayexpress
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