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Transcriptomicsbreast cancer cell lines ALDH+/-
Self-renewal and differentiation are two epigenetic programs that regulate pluripotency of stem cells. During oncogenesis, dysregulation of these two programs leads to the development of cancer stem cells (CSCs). Here, we used a pan genomic promoter microarray to determine the DNA methylation portra...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-MTAB-2236 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human breast cancer cell line SUM190 treated with Nectin4 ADC
Nectin-4 is a new therapeutic target in various carcinomas. We were interested in resistance to anti-nectin 4 ADC in breast cancer and the way to overcome it. Tumor RNAs were extracted from sensitive and resistant pre-clinical models. RNA-Seq libraries were created using Truseq RNA-Seq Library kit.
ORGANISM(S): Homo sapiens 
2022-05-14 | E-MTAB-11682 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization (CGH) of human breast cancer cell line SUM190 treated with Nectin4 ADC
Nectin-4 is a new therapeutic target in various carcinomas. We were interested in resistance to anti-nectin 4 ADC in breast cancer and the way to overcome it. Tumor DNA were extracted from sensitive and resistant pre-clinical models. Genomic profiles of samples were established by using array-CGH on...
ORGANISM(S): Homo sapiens 
2022-05-01 | E-MTAB-11681 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization (CGH) in glioblastomas
Ten pairs frozen Glioblastoma Multiforme (GBM) from initial and recurrent surgery after radio-chemotherapy were screened by CGH Array.
ORGANISM(S): Homo sapiens 
2021-03-01 | E-MTAB-10079 | biostudies-arrayexpress
TranscriptomicsGenome profiling by comparative genomic hybridization (CGH) in pediatric osteosarcoma
In some types of cancer, telomere length is maintained by the Alternative Lengthening of Telomeres (ALT) mechanism. We characterized a series of high-grade osteosarcomas from 22 non-metastatic and non-pre-treated pediatric patients. Using the presence of circular partially single-stranded extrachrom...
ORGANISM(S): Homo sapiens 
2022-05-13 | E-MTAB-11747 | biostudies-arrayexpress
TranscriptomicsInvestigation of molecular features involved in clinical responses and survival in advanced endometrial carcinoma
Hormone therapy (HT) is an effective treatment for metastatic endometrial carcinoma (mEC), with limited toxicity and low cost. We focused on molecular analysis of mECs treated by HT and, for the first time to date, we compared genomic profiles of paired metastasis and primary ECs. The main objective...
ORGANISM(S): Homo sapiens 
2022-03-16 | E-MTAB-11552 | biostudies-arrayexpress
TranscriptomicsProspective high-throughput genome profiling by comparative genomic hybridization (CGH) in advanced cancers.
We conducted a prospective monocenter clinical trial called PERMED01 to evaluate the number patients with locally advanced or metastatic cancer for whom identification of molecular alterations in tumor samples could lead to the delivery of a targeted therapy. Patients accessible to tumor biopsy were...
ORGANISM(S): Homo sapiens 
2021-03-01 | E-MTAB-9998 | biostudies-arrayexpress
TranscriptomicsCandidate luminal B breast cancer genes identified by genome, gene expression and DNA methylation profiling
To better understand Luminal B subtype we studied in 188 breast cancers of various molecular subtypes, DNA copy number aberrations (CNAs), DNA promoter methylation and gene expression profiles. Please note mRNA expression data already submitted for study: E-GEOD-21653.
ORGANISM(S): Homo sapiens 
2014-01-01 | E-MTAB-1861 | biostudies-arrayexpress
UnknownTOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT
Not available
S-SCDT-10_15252-EMMM_202215859 | biostudies-other
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