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UnknownIn vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche.
Short-term, systemic expression of the Yamanaka reprogramming factors (Oct-3/4, Sox2, Klf4 and c-Myc [OSKM]) has been shown to rejuvenate aging cells and promote tissue regeneration in vivo. However, the mechanisms by which OSKM promotes tissue regeneration are unknown. In this work, we focus on a s...
S-EPMC8149870 | biostudies-literature
UnknownInterspecies Chimerism with Mammalian Pluripotent Stem Cells.
Interspecies blastocyst complementation enables organ-specific enrichment of xenogenic pluripotent stem cell (PSC) derivatives. Here, we establish a versatile blastocyst complementation platform based on CRISPR-Cas9-mediated zygote genome editing and show enrichment of rat PSC-derivatives in several...
S-EPMC5679265 | biostudies-literature
UnknownIn Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation.
Current genome-editing systems generally rely on inducing DNA double-strand breaks (DSBs). This may limit their utility in clinical therapies, as unwanted mutations caused by DSBs can have deleterious effects. CRISPR/Cas9 system has recently been repurposed to enable target gene activation, allowing...
S-EPMC5732045 | biostudies-literature
UnknownHigh penetrance of acute intermittent porphyria in a Spanish founder mutation population and CYP2D6 genotype as a susceptibility factor.

Background

Acute intermittent porphyria (AIP) is a low-penetrant genetic metabolic disease caused by a deficiency of hydroxymethylbilane synthase (HMBS) in the haem biosynthesis. Manifest AIP (MAIP) is considered when carriers develop typical acute neurovisceral attacks with elevation of por...
S-EPMC6390611 | biostudies-literature
UnknownA method to construct a points system to predict cardiovascular disease considering repeated measures of risk factors.
Current predictive models for cardiovascular disease based on points systems use the baseline situation of the risk factors as independent variables. These models do not take into account the variability of the risk factors over time. Predictive models for other types of disease also exist that do c...
S-EPMC4756731 | biostudies-literature
UnknownEpisodic Salinity Management to Counter Climate Change Effects on Tidal Brackish and Fresh Wetlands.
The capacity of brackish and freshwater tidal marshes to accrete vertically in response to sea level rise is threatened where drought and salinity intrusion are being amplified by climate change. Episodic salinity management with purchased augmented freshwater is an option for two modest-sized tract...
S-EPMC12775006 | biostudies-literature
Unknown3D Culture Supports Long-Term Expansion of Mouse and Human Nephrogenic Progenitors.
Transit-amplifying nephron progenitor cells (NPCs) generate all of the nephrons of the mammalian kidney during development. Their limited numbers, poor in vitro expansion, and difficult accessibility in humans have slowed basic and translational research into renal development and diseases. Here, we...
S-EPMC7832086 | biostudies-literature
UnknownDietary supplementation with a wild green oat extract (Avena sativa L.) to improve wellness and wellbeing during smoking reduction or cessation: a randomized double-blind controlled study.

Objective

Smoking reduction or cessation are critical public health goals, given the well-documented risks of tobacco use to health. Reducing smoking frequency and cessation entirely are challenging due to nicotine addiction and withdrawal symptoms, which can significantly affect mental well...
S-EPMC11220258 | biostudies-literature
UnknownTMTC2 variant associated with sensorineural hearing loss and auditory neuropathy spectrum disorder in a family dyad.
Sensorineural hearing loss (SNHL) is a common form of hearing loss that can be inherited or triggered by environmental insults; auditory neuropathy spectrum disorder (ANSD) is a SNHL subtype with unique diagnostic criteria. The genetic factors associated with these impairments are vast and diverse, ...
S-EPMC6081214 | biostudies-literature
UnknownEfficacy of Boswellia serrata Extract and/or an Omega-3-Based Product for Improving Pain and Function in People Older Than 40 Years with Persistent Knee Pain: A Randomized Double-Blind Controlled Clinical Trial.
A single-center, randomized, double-blind, controlled clinical trial with four arms was conducted in healthy subjects with persistent knee discomfort (pain intensity on 1-10 cm visual analog scale (VAS) > 3) aged 40 years and older treated with a dietary supplement for 8 weeks. The study groups were...
S-EPMC10490338 | biostudies-literature
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