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TranscriptomicsImpact of Glucocorticoids and PI3K Inhibition on Gene Expression in Myeloma
We previously noted that combination glucocorticoids and PI3K inhibition induces synergistic cell death. To identify genes involved in myeloma cell death we examined mRNA expression in each individual treatment and in the combination. The glucocoriticoid resistant cells (MM.1RL) are used as a nega...
ORGANISM(S): Homo sapiens 
2015-12-07 | E-GEOD-64704 | biostudies-arrayexpress
TranscriptomicsIdentification of p38 beta as a therapeutic target for the treatment of Sézary Syndrome
Cutaneous T-Cell Lymphomas (CTCL) represent a group of hematopoietic malignancies that home to the skin and have no known molecular basis for disease pathogenesis. Sézary syndrome (SS) is the leukemic variant of CTCL. Currently, CTCL is incurable, highlighting the need for new therapeutic modalitie...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-59179 | biostudies-arrayexpress
TranscriptomicsETS2 and Mesp1 trans-differentiate human dermal fibroblasts into cardiac progenitors
We explored the role of mammalian ETS1/2 and Mesp homologues of cardiogenic transcription factors of Ciona intestinalis, to convert primary human dermal fibroblasts into cardiac progenitors. ETS1/2 and Mesp homologues of cardiogenic transcription factors of Ciona intestinalis, to convert primary hum...
ORGANISM(S): Mus musculus 
2012-06-30 | E-GEOD-29709 | biostudies-arrayexpress
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