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GenomicsIn vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse (Bisulfite-Seq)
Methylation of cytosines (5meC) is a widespread heritable DNA modification. During mammalian development, two global demethylation events are followed by waves of de novo DNA methylation. In vivo mechanisms of DNA methylation establishment are largely uncharacterized. Here we use Saccharomyces cerev...
ORGANISM(S): Saccharomyces cerevisiae 
2015-04-02 | E-GEOD-66905 | biostudies-arrayexpress
TranscriptomicsIntegrative AUF1 PAR-CLIP analysis uncovers AUF1 roles in translation and genome integrity
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-11-04 | E-GEOD-52977 | biostudies-arrayexpress
TranscriptomicsModerate stress acclimation provides immunity to stress by rewiring regulatory networks and inducing genes with protective functions in Cassava
Stress acclimation is an effective mechanism that plants acquired for adaption to dynamic environmental conditions. After undergoing cold acclimation, plants become more tolerant to cold stress. In order to understand the mechanism of cold acclimation, we performed a systematic, comprehensive study ...
ORGANISM(S): Manihot esculenta 
2014-08-18 | E-GEOD-52176 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling by array of Klf2 wild-type and Klf2-Null mESCs cultured under 2i
The self-renewing pluripotent state was first captured in mouse embryonic stem cells (mESCs) over two decades ago. The standard condition requires the presence of serum and LIF, which provide growth promoting signals for cell expansion. However, there are pro-differentiation signals which destabiliz...
ORGANISM(S): Mus musculus 
2014-06-04 | E-MTAB-2366 | biostudies-arrayexpress
GenomicsChIP-seq of Klf2 in mouse embryonic stem cells (Serum/LIF and 2i)
The self-renewing pluripotent state was first captured in mouse embryonic stem cells (mESCs) over two decades ago. The standard condition requires the presence of serum and LIF, which provide growth promoting signals for cell expansion. However, there are pro-differentiation signals which destabiliz...
ORGANISM(S): Mus musculus 
2014-06-04 | E-MTAB-2365 | biostudies-arrayexpress
ProteomicsbeadsEnrichment_L1-L4
L1-L4 mixture, Beads enrichment, Heparin-IEX
ORGANISM(S): Caenorhabditis Elegans (c. Elegans) 
2016-12-31 | PAe005573 | PeptideAtlas
ProteomicswholeCellExtract_L4-stage
L4 stage, whole protein extact, Heparin-IEX
ORGANISM(S): Caenorhabditis Elegans (c. Elegans) 
2016-12-31 | PAe005556 | PeptideAtlas
GenomicsWhole Genome and Exon Capture Sequencing of Bladder Cancers

One primary bladder cancer and paired peripheral blood sample were subjected to whole genome sequencing on an Illumina HiSeq 2000 platform. This technology was utilized to investigate the genetic basis of a durable remission of metastatic bladder cancer in a patient treated with everolimus, a dru...

phs000535.v1.p1 | EGA
UnknownTemperature-related mortality impacts under and beyond Paris Agreement climate change scenarios.
Not available
S-EPMC6217994 | biostudies-literature
ProteomicsA SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Purposing
An outbreak of the novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 170,000 people since the end of 2019, killed over 7,400, and caused worldwide social and economic disruption. SARS-CoV-2 infection has a mortality rate of 3.4% among confirmed case...
ORGANISM(S): Severe Acute Respiratory Syndrome Coronavirus 2 (ncbitaxon:2697049) Homo Sapiens (ncbitaxon:9606) 
2020-03-24 | MSV000085144 | MassIVE
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