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MetabolomicsComparative metabolomics reveals serum metabolites changes in goats during different developmental stages

Goats can provide meat, milk and skins for humans and are livestock with high economic benefits. However, despite their economic significance, the comprehensive analysis of goats' serum metabolic profile and its intricate alterations throughout their developmental journey remains conspicuously ab...

2024-06-04 | MTBLS8944 | MetaboLights
GenomicsComparative transcriptomics of B cell transdifferentiation in human and mouse. ChIP-Seq data
Exogenous overexpression of CEBPA transcription factor induces transdifferentiation from pro B cells into functional macrophages. Here we report the CEBPA binding ChIP-Seq data at 12 hours time point after induction of transdifferentiation in human BLaER1 cells (Rapino et al. 2013).
ORGANISM(S): Homo sapiens 
2022-01-01 | E-MTAB-7114 | biostudies-arrayexpress
TranscriptomicsExpression data from human lung epithelial cells after amorphous silica nanoparticle exposure for 40 passages
Amorphous silica nanoparticles induce malignant transformation and tumorigenesis of human lung epithelial cells. We used microarrays to detail the global programme of gene expression underlying the cellular malignant transformation induced by amorphous silica nanoparticles and identified distinct cl...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-82062 | biostudies-arrayexpress
TranscriptomicsEvolution of human-specific microRNA miR-941 [miRNA transfection]
miRNA-mediated gene expression silencing has previously been shown to be important for a variety of physiological and pathological processes. Here, we have explored the role of one bona fide human-specific miRNA (miR-941) in evolution of the human-specific expression and function. Using combination ...
ORGANISM(S): Macaca mulatta 
2012-12-20 | E-GEOD-35620 | biostudies-arrayexpress
TranscriptomicsATAC-seq of wild-type, Pbx1/Pbx2 double-knockout and pMsgn1-mut EpiSCs differentiated in vitro to pre-somitic mesoderm in the first 48 hours of differentiation.
In vertebrates, body axis elongation is fuelled by bipotent neuromesodermal progenitors (NMPs), which support the development of both spinal cord and paraxial mesoderm (PM). WNT signalling sustains both NMP expansion and PM differentiation, but the mechanism by which it distinguishes between these a...
ORGANISM(S): Mus musculus 
2021-07-21 | E-MTAB-9776 | biostudies-arrayexpress
TranscriptomicsGene Expression Profile for knocking down Tet1 in pre-iPSCs culturing in Vc medium.
Tet1 is a hydroxylase known for its role in the conversion of 5-methylcytosines (5mC) to 5-hydroxymethylcytosines (5hmC) involved in the possible active demethylation process and gene expression regulation. As somatic cell reprogramming involves the re-activation of pluripotency genes and the silenc...
ORGANISM(S): Mus musculus 
2013-10-27 | E-GEOD-48206 | biostudies-arrayexpress
GenomicsWhole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain
5-Hydroxymethylcytosine (hmC) is particularly abundant in mammalian brains with yetto be revealed functions. Here, we present genome-wide and single-base-resolutionmaps of hmC and mC in the human brain. We demonstrated that hmCs increasemarkedly from the fetal to the adult stage, and in the adult br...
ORGANISM(S): Homo sapiens 
2014-02-22 | E-GEOD-55249 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of IPS cells derived from peripheral blood cells: Reprogramming of T Cells from Human Peripheral Blood
Human induced pluripotent stem (iPS) cells derived from somatic cells of patients hold great promise for modelling human diseases. Dermal fibroblasts are frequently used for reprogramming, but require an invasive skin biopsy and a prolonged period of expansion in cell culture prior to use. Here, we ...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-22167 | biostudies-arrayexpress
UnknownPharmacokinetic Comparisons of Eight Active Components from Raw Farfarae Flos and Honey-Processed Farfarae Flos after Oral Administration in Rats by UHPLC-MS/MS Approaches.
Not available
S-EPMC7256776 | biostudies-literature
MetabolomicsSelective galactose culture condition reveals distinct metabolic signatures in pyruvate dehydrogenase and complex I deficient human skin fibroblasts

INTRODUCTION: A decline in mitochondrial function represents a key factor of a large number of inborn errors of metabolism, which lead to an extremely heterogeneous group of disorders.

OBJECTIVES: To gain insight into the biochemical consequences of mitocho...

2021-10-06 | MTBLS761 | MetaboLights
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