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TranscriptomicsGene profiling on mandibular arches (MdPA1) from Tbx1+/+ and Tbx1-/- mouse embryos
Velo-cardio-facial syndrome/DiGeorge syndrome/22q11.2 deletion syndrome (22q11DS) patients have a submucous cleft palate, velo-pharyngeal insufficiency associated with hypernasal speech, facial muscle hypotonia and feeding difficulties. Inactivation of both alleles of mouse Tbx1, encoding a T-box tr...
ORGANISM(S): Mus musculus 
2014-05-21 | E-GEOD-30980 | biostudies-arrayexpress
TranscriptomicsGene profiling on mandibular arches (MdPA1) from Tbx1+/+ and Tbx1-/- mouse embryos E9.5
Velo-cardio-facial syndrome/DiGeorge syndrome/22q11.2 deletion syndrome (22q11DS) patients have a submucous cleft palate, velo-pharyngeal insufficiency associated with hypernasal speech, facial muscle hypotonia and feeding difficulties. Inactivation of both alleles of mouse Tbx1, encoding a T-box tr...
ORGANISM(S): Mus musculus 
2014-05-21 | E-GEOD-35013 | biostudies-arrayexpress
TranscriptomicsExpression data from mesodermal Tbx1-knockout ears at E12.5
The T-box transcription factor Tbx1 is expressed in the otic vesicle and surrounding periotic mesenchyme during inner ear development. Mesenchymal Tbx1 is essential for inner ear development, with conditional mutants displaying defects in both auditory and vestibular systems. We have previously iden...
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-34062 | biostudies-arrayexpress
TranscriptomicsExpression data from mesodermal Tbx1-knockout otic vesicles at E11.5
The T-box transcription factor Tbx1 is expressed in the otic vesicle and surrounding periotic mesenchyme during inner ear development. Mesenchymal Tbx1 is essential for inner ear development, with conditional mutants displaying defects in both auditory and vestibular systems. We have previously iden...
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-34064 | biostudies-arrayexpress
TranscriptomicsExpression data from mesodermal Tbx1-knockout otic vesicles and periotic mesenchyme at E11.5
The T-box transcription factor Tbx1 is expressed in the otic vesicle and surrounding periotic mesenchyme during inner ear development. Mesenchymal Tbx1 is essential for inner ear development, with conditional mutants displaying defects in both auditory and vestibular systems. We have previously iden...
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-34065 | biostudies-arrayexpress
TranscriptomicsReduced dosage of β-catenin genetically rescues intracardiac anomalies in a Tbx1 conditional null mouse model of 22q11.2 deletion syndrome
Approximately 60-70% of patients with 22q11.2 deletion syndrome (22q11.2DS; velo-cardio-facial syndrome/DiGeorge syndrome) have cardiac outflow tract anomalies including persistent truncus arteriosus (PTA) as the most severe defect. Among the genes in the 22q11.2 region, TBX1, encoding a T-box trans...
ORGANISM(S): Mus musculus 
2016-09-01 | E-GEOD-78125 | biostudies-arrayexpress
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