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ProteomicsMulti-omics profiling reveals systemic rejuvenation of the aged kidney through senolytic therapy
Cellular senescence is a key driver of kidney aging, leading to functional decline and increased susceptibility to chronic kidney disease. While the senolytic combination of dasatinib and quercetin (D+Q) has shown promise in mitigating age-related pathologies, its long-term effects and underlying mu...
ORGANISM(S): Homo Sapiens 
2026-03-24 | PXD076057 |
ProteomicsDDX5-sIL-36R in keratinocytes controls skin inflammation
The DEAD-box (DDX) proteins function in diverse cellular processes including RNA alternative splicing, and are linked to immune-mediated diseases. However, little is known about the roles of DDXs in skin inflammatory diseases. Here, we show that DDX5, one of the founding members of the DDX RNA helic...
ORGANISM(S): Homo Sapiens 
2020-09-09 | PXD021379 |
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