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TranscriptomicsTranscriptomic effects of Capridine on the acute promyelocytic leukemia HL-60 cell line
We used Agilent human gene expression arrays to test whether Capridine, a chemotherapeutic agent with specificity towards prostate cancer, deregulates the genomic fabric of acute myeloyd leukemia in HL-60 cells. This cell line was derived at the National Cancer Institute from a 36-year-old woman wit...
ORGANISM(S): Homo sapiens 
2015-08-27 | E-GEOD-72415 | biostudies-arrayexpress
TranscriptomicsRemodeling of DNA transcription genomic fabric in Capridine-treated LNCaP human prostate cancer cell line
Capridine is a chemotherapeutic agent with specificity towards prostate cancer and minimal bone marrow toxicity. Capridine structure is consistent with a classical DNA intercalating agent, although its DNA intercalation property does not fully correlate with its anti prostate cancer specific activit...
ORGANISM(S): Homo sapiens 
2015-08-27 | E-GEOD-72414 | biostudies-arrayexpress
TranscriptomicsRemodeling of major genomic fabrics and their interplay in Capridine-treated DU145 classic human prostate cancer
Our preclinical developmental program identified Capridine as a chemotherapeutic agent that had specificity towards prostate cancer with minimal bone marrow toxicity. In human prostate cancer xenograft studies both androgen responsive and non-responsive tumors were inhibited by a weekly therapeutic ...
ORGANISM(S): Homo sapiens 
2015-08-25 | E-GEOD-72333 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Basmati T-DNA insertional mutant lines
The aim of this study was to look for the changes at the transcriptome level caused by the same T-DNA cassette in three mutants of Basmati 370 with different phenotypes. The comparative analysis of differentially expressed genes was conducted individually and collectively for all three mutants. RNA ...
ORGANISM(S): Oryza sativa Indica Group 
2013-12-31 | E-GEOD-31248 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type Basmati 370 and its T-DNA insertional mutant OsAPC6.
The aim of this study was to look for the changes at the transcriptome level caused by the insertion of a T-DNA in mutant of Basmati 370 with dwarf phenotype. The comparative analysis of differentially expressed genes was conducted individually and collectively for both. RNA from wild type Basmati ...
ORGANISM(S): Oryza sativa Indica Group 
2013-12-31 | E-GEOD-31200 | biostudies-arrayexpress
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