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TranscriptomicsPitx1 Haploinsufficiency Causes Clubfoot in Humans and Mice
To identify genes regulated by Pitx1 during early hindlimb development, we compared gene expression differences between hindlimb buds from E12.5 Pitx1+/+ and Pitx1-/- mice on the Illumina MouseRef-8 expression Bead Chip. Genes involved in muscle development GeneGO processes were highly enriched in ...
ORGANISM(S): Mus musculus 
2011-11-21 | E-GEOD-27363 | biostudies-arrayexpress
GenomicsGenetic Associations in Idiopathic Talipes Equinovarus (Clubfoot) - GAIT

Isolated clubfoot or idiopathic talipes equinovarus (ITEV) is one of the five most common birth defects, affecting approximately 4,000 newborns each year in the US. While the orthopedic care of these children has improved, long-term problems persist and the health care costs are significant. Stud...

phs000314.v1.p1 | EGA
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