Sort   by:  
 Page size 
MetabolomicsOverexpression of tlr5 adrffects gut microbiota resistance to Salmonella infection

BACKGROUND: The gut microbiome and the host immune system interact synergistically to maintain intestinal health and defend against infections. Toll-like receptor 5 (TLR5), known for recognizing bacterial flagellin, plays a pivotal role in this regulatory network. Despite significant advances in ...

2024-07-25 | MTBLS10592 | MetaboLights
MetabolomicsAlterations in the gut microbiota and metabolic profiles coincide with intestinal damage in mice with a bloodborne Candida albicans infection
Candida albicans is an opportunistic fungus that can threaten life especially in patients with candidemia. The morbidity and mortality of candidemia originating from a central venous catheter (CVC) and illicit intravenous drug use (IVDU) are increasing. However, the mechanism underlying the bloodbor...
2021-04-13 | MTBLS1918 | MetaboLights
MetabolomicsDiallyl disulfide (DADS) ameliorates intestinal Candida albicans infection by modulating the gut microbiota and metabolites and providing intestinal protection in mice
Diallyl disulfide (DADS), a garlic extract also known as allicin, has been reported to have numerous biological activities, including anticancer, antifungal, and inflammation-inhibiting activities, among others. Although many studies have assessed whether DADS can treat Candida albicans infec...
2022-05-03 | MTBLS3750 | MetaboLights
MetabolomicsGut microbiota within-host evolution enforces colonization resistance against enteric infection

Limited resource availability in the gut promotes competitive interactions between bacteria, which drive adaptive within-host evolution. While the role of bacterial adaptive evolution of bacterial communities has been extensively studied, its functional implications for host physiology remain unk...

2026-08-03 | MTBLS10327 | MetaboLights
MetabolomicsA gut Eggerthella lenta–derived metabolite impairs neutrophil function to aggravate bacterial lung infection
The “gut-lung” axis is crucial for the chronic infection in bronchiectasis. However, the responsible microbe and the mechanism in the “gut-lung” axis of bronchiectasis are still in demand for precise elucidation. Here, we reported that Eggerthella lenta in the gut and taurine ursodeoxycholic acid (T...
2025-02-27 | MTBLS9522 | MetaboLights
MetabolomicsDietary iron attenuates Clostridioides difficile infection via modulating intestinal immune response and gut microbiota

Clostridioides difficile (C. difficile) causes antibiotic-associated diarrhea. Susceptibility to C. difficile infection (CDI) is largely affected by the gut microbiota, which in turn is influenced by diet. However, the mechanism underlying the interplay between diet and the gut mic...

2024-11-12 | MTBLS11336 | MetaboLights
MetabolomicsParabacteroides distasonis alleviates Clostridioides difficile infection by reshaping bile acid metabolism and the gut microbiota

The aim of this study was to establish a mouse model of Clostridioides difficile infection (CDI) and to investigate the effects of intervention with live Parabacteroides distasonis and its culture supernatant on the fecal bile acid pool using a targeted metabolomics approach. By...

2026-02-04 | MTBLS13831 | MetaboLights
MetabolomicsLactiplantibacillus plantarum HB: A koumiss-derived Lactobacillus alleviates Toxoplasma gondii infection through regulating gut microbiota and metabolism

Toxoplasma gondii (T. gondii) is an obligate intracellular protozoan parasite capable of infecting nearly all warm-blooded animals, including humans, with epidemiological studies indicating remarkably high global infection. However, due to its complex life cycle, no effective vaccine has bee...

2025-09-12 | MTBLS12987 | MetaboLights
MetabolomicsA Multi-Omic View of Host-Pathogen-Commensal Interplay in Salmonella-Mediated Intestinal Infection
The potential for commensal microorganisms indigenous to a host (the microbiome or microbiota) to alter infection outcome by influencing host-pathogen interplay is largely unknown. We used a multi-omics systems approach, incorporating proteomics, metabolomics, glycomics, and metagenomics, to explore...
2014-06-24 | MTBLS96 | MetaboLights
MetabolomicsResearch on vaccine immunity based on gut microbiota and metabolomics The impact of pseudorabies virus infection

Pseudorabies virus infection causes intestinal flora disorder in animals, leading to diarrhea. To explore the effect of inactivated pseudorabies vaccine immunization on pseudorabies virus infection, this study sequenced the serum metabolome and intestinal microbiota of Hu sheep, analyzed their di...

2025-09-03 | MTBLS12933 | MetaboLights
Sort   by:  
 Page size