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MetabolomicsSubcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages
Tuberculosis, caused by the intracellular pathogen Mycobacterium tuberculosis, remains the world's deadliest infectious disease. Sterilizing chemotherapy requires at least 6 months of multidrug therapy. Difficulty visualizing the subcellular localization of antibiotics in infected host cells means t...
2020-12-07 | MTBLS959 | MetaboLights
MetabolomicsDiagnostic utility of clinicodemographic, biochemical and metabolite variables to identify viable pregnancies in a symptomatic cohort during early gestation.

Study question: Can a novel machine learning pipeline create predictive models that identify a composite biomarker to differentiate live normally sited pregnancies (LNSP) from non-viable pregnancies in women presenting with pain and/or bleeding in early gestation?

Summary answer: Serum met...

2025-08-14 | MTBLS6219 | MetaboLights
MetabolomicsA polyamine-centric blood-based metabolite panel predictive of poor response to CAR T-cell therapy in large B cell lymphoma

Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy for relapsed or refractory (r/r) large B-cell lymphoma (LBCL) results in durable response in only a subset of patients. MYC overexpression in LBCL tumors is associated with poor response to treatment. We tested whether a MYC-driven polyamin...

2022-10-31 | MTBLS5381 | MetaboLights
ProteomicsEnhancement of Tryptic Peptide Signals from Tissue Sections using MALDI IMS Post-ionization (MALDI-2)
Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) allows for highly multiplexed, unlabeled mapping of analytes from tissue sections. However, further work is needed to improve sensitivity and depth of coverage for protein and peptide IMS. Laser-based post-ionization ...
ORGANISM(S): Homo sapiens (Human) 
2021-12-30 | PXD023877 | Pride
Kidney Imaging mass spectrometry Maldi-2 Lc-ms/ms 
ProteomicsIntegrative Structural Characterization of the Human Canonical and Non-canonical Cop9 Signalosome Complexes
The COP9 signalosome (CSN) is an evolutionarily conserved protein complex that functions as a deneddylase to inactivate Cullin-RING E3 ligases for controlling protein ubiquitination. CSN possesses structural flexibility that is important for its activation upon binding to a diverse array of CRLs. Th...
ORGANISM(S): Homo sapiens (Human) 
2020-02-04 | PXD014673 | Pride
Mass spectrometry Sulfoxided based cross-linkers Cross-linking Intergrative modeling platform (imp) Ms-cleavable Cop9 signalosme 
UnknownEvidence of emotion dysregulation as a core symptom of adult ADHD: A systematic review.
Not available
S-EPMC9821724 | biostudies-literature
MetabolomicsMaHPIC Experiment 07A and 07B: Quantitative Metabolomics from Macaca fascicularis infected with Plasmodium knowlesi sporozoites to produce and integrate clinical, hematological, parasitological, omics, telemetric and histopathological measures of acute primary infection
E07 was originally planned and implemented prior to E06. The E07 cohort was inoculated with freshly dissected P. knowlesi sporozoites on 11/01/16. However, for unexplained reasons blood-stage parasitemias did not occur. Consequently, the E07 cohort was reinoculated with cryopreserved P. kn...
2019-01-11 | MTBLS822 | MetaboLights
TranscriptomicsTranscription profiling of Arabidopsis treated with Cordycepin
mRNA degradation provides a powerful means for controlling gene expression during growth, development, and many physiological transitions in plants and other systems. Rates of decay help define the steady state levels to which transcripts accumulate in the cytoplasm and determine the speed with whic...
ORGANISM(S): Arabidopsis thaliana 
2005-09-02 | E-SMDB-1543 | biostudies-arrayexpress
TranscriptomicsCordycepin time course: Identification of unstable transcripts
mRNA degradation provides a powerful means for controlling gene expression during growth, development, and many physiological transitions in plants and other systems. Rates of decay help define the steady state levels to which transcripts accumulate in the cytoplasm and determine the speed with whic...
ORGANISM(S): Arabidopsis thaliana 
2005-09-09 | E-GEOD-3270 | biostudies-arrayexpress
UnknownLong-term antibody response following SPUTNIK V primary vaccination in healthcare workers with and without history of SARS-CoV-2 infection: Prospective cohort study from a hospital in Argentina.
Not available
S-EPMC9213035 | biostudies-literature
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