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TranscriptomicsSymmetric Bis-benzimidazoles Are Potent Anti-Staphylococcal Agents with Dual Inhibitory Mechanisms against DNA Gyrase
Various bis-benzimidazole derivatives have been reported to possess activity against Gram-positive pathogens. No mechanism of action has been elucidated to fully account for the antibacterial activity of this class of compounds. A group of symmetric bis-benzimidazoles (BBZ) designed as anticancer ag...
ORGANISM(S): Staphylococcus aureus 
2012-10-14 | E-BUGS-106 | biostudies-arrayexpress
TranscriptomicsGyrase binding in wild type and gyrA D82G mutant
Raw data for spatial pattern analysis of gyrase binding in E. coli MG1655 wild type and gyrA D82G mutant (ChIP-chip data)
ORGANISM(S): Escherichia coli 
2004-09-09 | E-GEOD-1735 | biostudies-arrayexpress
TranscriptomicsTopoisomerase function in E. coli replication fork movement
Analysis of topoisomerase function in bacterial replication fork movement: use of DNA microarrays. We used DNA microarrays of the Escherichia coli genome to trace the progression of chromosomal replication forks in synchronized cells. We found that both DNA gyrase and topoisomerase IV (topo IV) prom...
ORGANISM(S): Escherichia coli 
2001-07-30 | E-GEOD-8 | biostudies-arrayexpress
TranscriptomicsTranscriptional consequences of DNA gyrase inhibition
DNA gyrase is an essential enzyme whose activity is required for DNA replication and chromosome maintenance. Inhibition of gyrase results in multiple physiological effects including changes in DNA superhelicity, replication arrest and DNA damage. Using genetic, genomic, statistical and biochemical t...
ORGANISM(S): Escherichia coli 
2006-03-10 | GSE4408 | GEO
GenomicsTranscription facilitated genome-wide recruitment of topoisomerase I and DNA gyrase
Transcription facilitated genome-wide recruitment of topoisomerase I and DNA gyrase
PRJNA338794 | ENA
GenomicsFluoroquinolone-induced gyrase cleavage sites
Fluoroquinolone-induced gyrase cleavage sites
PRJNA851452 | ENA
GenomicsGyrase binding in wild type and gyrA D82G mutant
Raw data for spatial pattern analysis of gyrase binding in E. coli MG1655 wild type and gyrA D82G mutant (ChIP-chip data) Keywords: other
ORGANISM(S): Escherichia coli 
2004-09-09 | GSE1735 | GEO
GenomicsTranscription facilitated genome-wide recruitment of topoisomerase I and DNA gyrase
Genome-wide distribution of topoisomerase I and DNA gyrase is directed by transcription induced supercoiling
ORGANISM(S): Mycobacterium tuberculosis H37Ra Mycobacterium tuberculosis H37Rv 
2017-01-31 | GSE85357 | GEO
GenomicsDNA supercoiling differences in bacteria result from disparate DNA gyrase activation by polyamines
DNA supercoiling differences in bacteria result from disparate DNA gyrase activation by polyamines
PRJNA633508 | ENA
TranscriptomicsTranscription profiling by array of human primary hepatocytes treated with trovafloxacin
Trovafloxacin is a broad spectrum antibiotic that inhibits the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. Specific members of this drug family display high activity against eukaryotic type II topoisomerase, as well as cultured mammal...
ORGANISM(S): Homo sapiens 
2008-10-10 | E-GEOD-11941 | biostudies-arrayexpress
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