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GenomicsH2A.X native ChIP-Seq in ESC and iPSC: Histone Variant H2A.X Mediated Epigenetic Mechanisms are Critical for Maintaining Genome Stability and Pluripotency in ES and iPS Cells
It is well-known that embryonic stem cells (ESC) are much more sensitive to replication-induced stress than differentiated cells but the underpinning mechanisms are largely unknown. H2A.X, a minor variant of H2A, constitutes only 1-10% of the mammalian genome. H2A.X plays a well-known for role in t...
ORGANISM(S): Mus musculus 
2014-09-07 | E-GEOD-42306 | biostudies-arrayexpress
GenomicsH2A.X native ChIP-Seq in TSC; Histone Variant H2A.X Mediated Epigenetic Mechanisms are Critical for Pluripotency in ES and iPS Cells
With the advent of the induced pluripotent stem cell (iPSC) technology, how to distinguish the developmental potentials of the iPSC clones with molecular approaches becomes an imperative issue. Herein, we demonstrated that histone variant H2A.X plays an unexpected role in distinguishing the develop...
ORGANISM(S): Mus musculus 
2014-09-07 | E-GEOD-57216 | biostudies-arrayexpress
GenomicsThe developmental potential of iPSCs is greatly influenced by the selection of the reprogramming factors (SNEL iPSC and H2A.X deposition pattern)
Induced pluripotent stem cells (iPSCs) are commonly generated by transduction of Oct4, Sox2, Klf4 and Myc (OSKM) into somatic cells. Though iPSCs are pluripotent, they frequently exhibit high variation in their quality as measured by chimera contribution and tetraploid (4n) complementation. Thus, im...
ORGANISM(S): Mus musculus 
2014-09-07 | E-GEOD-55731 | biostudies-arrayexpress
TranscriptomicsHistone Variant H2A.X Plays Novel Roles in Cell Lineage Commitment and Genomic Stability in ESC and iPSC
Herein, we demonstrated that the cell lineage commitment is unexpectedly regulated by the novel functions of H2A.X, a histone variant which was only well-known for its role in genome integrity maintenance previously. Surprisingly, only in ESCs but not differentiated cells, H2A.X is specifically targ...
ORGANISM(S): Mus musculus 
2014-09-07 | E-GEOD-49147 | biostudies-arrayexpress
TranscriptomicsCNV analysis of iPS cell lines and H2A.X knockout ES cell
It is well-known that embryonic stem cells (ESC) are much more sensitive to replication-induced stress than differentiated cells but the underpinning mechanisms are largely unknown. H2A.X, a minor variant of H2A, constitutes only 1-10% of the mammalian genome. H2A.X plays a well-known for role in t...
ORGANISM(S): Mus musculus 
2014-09-07 | E-GEOD-42266 | biostudies-arrayexpress
GenomicsH2A.X function in mouse ESC and iPSC (ChIPSeq and CNVs)
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-09-07 | E-GEOD-42309 | biostudies-arrayexpress
TranscriptomicsThe histone variant H2A.X is a regulator of Epithelial–Mesenchymal Transition
The epithelial-mesenchymal transition (EMT), considered essential for metastatic cancer, has been a focus of much research, but important questions remain. Here, we show that silencing or removing H2A.X, a histone H2A variant involved in cellular DNA repair and robust growth, induced mesenchymal-lik...
ORGANISM(S): Homo sapiens 
2016-02-10 | E-GEOD-75444 | biostudies-arrayexpress
GenomicsConversion of Fibroblasts into Functional Trophoblast Stem-like Cells
Here we demonstrate the generation of stable induced trophoblast stem cells (iTSCs) from fibroblasts by the transient expression of Gata3, Eomes and Tfap2c. Transcriptome and methylome analyses and functional assays such as hemorrhagic lesion formation and placenta contribution suggested a high deg...
ORGANISM(S): Mus musculus 
2016-07-05 | E-GEOD-70234 | biostudies-arrayexpress
GenomicsH2A.X promotes endosperm-specific DNA methylation in Arabidopsis thaliana
H2A.X promotes endosperm-specific DNA methylation in Arabidopsis thaliana
PRJNA978578 | ENA
GenomicsH2A.X SMRT-ChIP
It has widely accepted that 5-methylcytosine is the only form of DNA methylation in mammalian genomes, whereas the other forms, such as N6-methyladenine, primarily exist in prokaryotes and only a few eukaryotes. Herein, we demonstrated the surprising presence of N6-methyladenine in mammalian genome...
ORGANISM(S): Mus musculus 
2016-03-30 | E-GEOD-71940 | biostudies-arrayexpress
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