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GenomicsEpendymoma associated protein EZHIP inhibits PRC2 through a H3 K27M like mechanism (ChIP-Seq H2K27me3)
Ependymoma associated protein EZHIP inhibits PRC2 through a H3 K27M like mechanism (ChIP-Seq H2K27me3)
PRJNA513313 | ENA
GenomicsEpendymoma associated protein EZHIP inhibits PRC2 through a H3 K27M like mechanism (ChIP-Seq H2K27me3)
to understand the genome wide alterations in PRC2-mediated K27me3 and PRC1 distribution caused by oncohistone K27M mutation or novel PRC2 inhibitor – EZHIP
ORGANISM(S): Mus musculus 
2019-04-08 | GSE124740 | GEO
UnknownEzh2 knockout in mesenchymal cells causes enamel hyper-mineralization.
Not available
S-EPMC8290883 | biostudies-literature
GenomicsChIP-on-chip analysis of H3K27me3 levels in leaves and calli
In plants, multiple detached tissues are capable of forming a pluripotent cell mass, termed callus, when cultured with appropriate plant hormones. Recent studies demonstrated that callus resembles the tip of a root meristem, even if it is derived from aerial organs. However, the underlying mechanism...
ORGANISM(S): Arabidopsis thaliana 
2012-01-01 | GSE34596 | GEO
GenomicsModulation of activated T cells by transient EZH2 inhibition [ChIP-Seq]
The histone methyltransferase enhancer of zeste homolog 2 (EZH2)-mediated epigenetic regulation of T cell differentiation in acute infection has been extensively investigated. However, the role of EZH2 in T cell exhaustion remains under-explored. Here, using in vitro exhaustion models, we demonstrat...
ORGANISM(S): Mus musculus 
2024-09-26 | GSE233536 | GEO
TranscriptomicsModulation of activated T cells by transient EZH2 inhibition [RNA-Seq]
The histone methyltransferase enhancer of zeste homolog 2 (EZH2)-mediated epigenetic regulation of T cell differentiation in acute infection has been extensively investigated. However, the role of EZH2 in T cell exhaustion remains under-explored. Here, using in vitro exhaustion models, we demonstrat...
ORGANISM(S): Mus musculus 
2024-09-26 | GSE233535 | GEO
UnknownSChLAP1 promotes prostate cancer development through interacting with EZH2 to mediate promoter methylation modification of multiple miRNAs of chromosome 5 with a DNMT3a-feedback loop.
Not available
S-EPMC7884413 | biostudies-literature
GenomicsCrol contributes to PRE-mediated repression and Polycomb group proteins recruitment in Drosophila (ChIP-seq)
The Polycomb group (PcG) proteins are fundamental epigenetic regulators that control the repressive state of target genes in multicellular organisms. One of the open questions is defining the mechanisms of PcG recruitment to chromatin. In Drosophila, the crucial role in PcG recruitment is thought to...
ORGANISM(S): Drosophila melanogaster 
2023-04-19 | GSE202870 | GEO
TranscriptomicsCrol contributes to PRE-mediated repression and Polycomb group proteins recruitment in Drosophila (RNA-seq)
The Polycomb group (PcG) proteins are fundamental epigenetic regulators that control the repressive state of target genes in multicellular organisms. One of the open questions is defining the mechanisms of PcG recruitment to chromatin. In Drosophila, the crucial role in PcG recruitment is thought to...
ORGANISM(S): Drosophila melanogaster 
2023-04-19 | GSE202832 | GEO
TranscriptomicsLSM2-8 and XRN-2 contribute to the silencing of H3K27me3 marked genes through targeted RNA decay II
The LSM2-8 complex specifically targets nuclear RNAs generated from loci bearing histone H3K27me3 for degradation through the exonuclease XRN-2 In fission yeast and plants RNA-processing pathways including co-transcriptional degradation of nuclear mRNAs contributes to heterochromatic gene silencing ...
ORGANISM(S): Caenorhabditis elegans 
2020-02-12 | GSE133356 | GEO
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