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GenomicsEffects on the transcriptome upon deletion of distal elements are not correlated with the size of H3K27Ac peaks in human cells
Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with increased risk for colorectal cancer (CRC). A molecular understanding of the functional consequences of this genetic variation is complicated because most GWAS SNPs are located in non-coding...
ORGANISM(S): Homo sapiens 
2016-01-12 | E-GEOD-72631 | biostudies-arrayexpress
GenomicsEnhancer Analysis in Peripheral Nerve: ChIP-seq of H3K27ac in P15 sciatic nerve
ChIP-seq of H3K27ac in P15 sciatic nerve 1 H3K27ac ChIP sample, with respective input
ORGANISM(S): Rattus norvegicus 
2015-04-01 | E-GEOD-64971 | biostudies-arrayexpress
GenomicsH3K27Ac and H3K4me1 ChIP-seq in Rex1GFPd2 mouse embryonic stem cell line
Chromatin immunoprecipitation using H3K27Ac and H3K4me1 antibodies in Rex1GFPd2 mouse ES cells (parental line; E14Tg2a)
ORGANISM(S): Mus musculus 
2014-06-24 | E-MTAB-2282 | biostudies-arrayexpress
GenomicsGenome-wide profiling of H3K27ac (ChIP-seq) in IMR90 cells
To determine the genome-wide pattern of H3K27ac in IMR90 (ATCC CCL-186) cells we performed ChIP-seq upon hormone treatment (1.5 h, 1 M dexamethasone).
ORGANISM(S): Homo sapiens 
2018-04-12 | E-MTAB-5355 | biostudies-arrayexpress
GenomicsGenome-wide maps of MEF2C and H3K27ac localization in HUVECs
MEF2C is one of the substantially expressed transcriptional factors in endothelial cells, but its genomic localization is unknown. This time, we established a new antibody for MEF2C, and performed ChIP-seq to identify MEF2C binding site in whole genome manner. H3K27Ac binding sites were also detec...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-32644 | biostudies-arrayexpress
GenomicsChIP-seq data of HNF4A, CEBPA, FOXA1, H3K27ac,
We profiled the genome-wide occupancy of three tissue-specific transcription factors, HNF4A, CEBPA and FOXA1, as well as the genome-wide occurrence of the histone mark, H3K4me3 in the livers of two inbred parental mouse strains (C57BL/6J and CAST/EiJ) and their F1 crosses. We also included H3K27ac d...
ORGANISM(S): Mus 
2016-06-30 | E-MTAB-4089 | biostudies-arrayexpress
GenomicsGenome-wide maps of H3K27ac, PPARβ/δ and Pol II localization in HUVECs
H3K27Ac is one of the expressed enhancer markers, PPARβ/δ is a transcription factor and Pol II (RNA polymerase II) is an enzyme which catalyzes the transcription of DNA to synthesize precursors of mRNA and most snRNA and microRNA. These genomic localization in endothelial cells is unknown in endothe...
ORGANISM(S): Homo sapiens 
2014-03-06 | E-GEOD-50144 | biostudies-arrayexpress
GenomicsIdentification of a novel Aire-regulating cis-regulatory element using H3K27ac ChIP-seq
Thymic central tolerance is essential to preventing autoimmunity. In medullary thymic epithelial cells (mTECs), the Autoimmune regulator (Aire) gene plays an essential role in this process by driving the expression of a diverse set of tissue-specific antigens (TSAs), which are presented and help tol...
ORGANISM(S): Mus musculus 
2015-10-23 | E-GEOD-74257 | biostudies-arrayexpress
GenomicsIdentify acetylation marks in adult mouse L4 vertebrae gene promoter regions from maternal high fat diet dams using H3K27ac ChIP-Seq
Genes with increased H3K27ac marks in their promoters were found in adult mice L4 vertebrae from mice using H3K27ac ChIP-Seq. Recent data suggests that in animals and humans that a maternal diet high in fat leads to poor bone growth and development in offspring. Genes with increased H3K27ac epigenet...
ORGANISM(S): Mus musculus 
2022-05-31 | E-MTAB-11718 | biostudies-arrayexpress
GenomicsIdentify acetylation marks from embryonic calvaria cell gene promoter regions from maternal high fat or control diet dams using H3K27ac ChIP-Seq.
Genes with increased H3K27ac marks in their promoters were found in mice embryonic calvaria cells using H3K27ac ChIP-Seq. Recent data suggests that in animals and humans that a maternal diet high in fat leads to poor bone growth and development in offspring. Genes with increased H3K27ac epigenetic m...
ORGANISM(S): Mus musculus musculus 
2022-05-31 | E-MTAB-11712 | biostudies-arrayexpress
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