Sort   by:  
 Page size 
MetabolomicsDietary Glutamine Supplementation Mitigates Age-Associated Cardiac Decline by Restricting H3K27me3

Epigenetic alterations are central drivers of cardiovascular aging, with histone modifications regulating gene expression through chromatin remodeling and changes in DNA accessibility. However, the mechanisms underlying these epigenetic shifts in the aging heart remain poorly defined. Here, we id...

2026-02-11 | MTBLS13890 | MetaboLights
GenomicsGenome-wide maps of H3K9Me3, H3K27Me and Brg1 distribution between Wild Type (Wt) and Actb-/- (KNO) Mouse Embryonic Fibroblast
Using Chromatin-immunoprecipitation and NGS, we profiled the genome-wdie H3K9Me3, H3K27Me and Brg1 distribution between Wild Type (Wt) and Actb-/- (KNO) Mouse Embryonic Fibroblast
ORGANISM(S): Mus musculus 
2017-07-01 | GSE100096 | GEO
GenomicsMus musculus
Genome-wide maps of H3K9Me3, H3K27Me and Brg1 distribution between Wild Type (Wt) and Actb-/- (KNO) Mouse Embryonic Fibroblast
PRJNA390667 | ENA
TranscriptomicsProduct binding enforces the genomic specificity of a yeast Polycomb repressive complex
We characterize the Polycomb system that assembles repressive subtelomeric domains of H3K27 methylation (H3K27me) in the yeast Cryptococcus neoformans. Purification of this PRC2-like protein complex reveals orthologs of animal PRC2 components as well as a chromodomain-containing subunit, Ccc1, which...
ORGANISM(S): Cryptococcus neoformans 
2014-11-10 | GSE61550 | GEO
OtherThe shelterin subunit TRF-1 mediates PRC2 function at ectopic telomere repeats in Neurospora crassa [HiC]
Telomeres are crucial for maintaining chromosomal integrity and are characterized by repetitive sequences, which may be stabilized by the shelterin protein complex and/or by formation of secondary structures, such as G-quadruplexes (G4 DNA). Frequently, subtelomeric regions are decorated with di- an...
ORGANISM(S): Neurospora crassa 
2026-03-30 | GSE301562 | GEO
GenomicsThe shelterin subunit TRF-1 mediates PRC2 function at ectopic telomere repeats in Neurospora crassa [ChIP-seq]
Telomeres are crucial for maintaining chromosomal integrity and are characterized by repetitive sequences, which may be stabilized by the shelterin protein complex and/or by formation of secondary structures, such as G-quadruplexes (G4 DNA). Frequently, subtelomeric regions are decorated with di- an...
ORGANISM(S): Neurospora crassa 
2026-03-30 | GSE301563 | GEO
GenomicsLoss of HP1 causes depletion of H3K27me3 from facultative heterochromatin and gain of H3K27me2 at constitutive heterochromatin
Methylated lysine 27 on histone H3 (H3K27me) marks repressed "facultative heterochromatin", including developmentally regulated genes in plants and animals. The mechanisms responsible for localization of H3K27me are largely unknown, perhaps in part because of the complexity of epigenetic regulatory ...
ORGANISM(S): Neurospora crassa 
2015-11-03 | GSE68897 | GEO
UnknownProduct binding enforces the genomic specificity of a yeast polycomb repressive complex.
Not available
S-EPMC4303595 | biostudies-literature
TranscriptomicsRNA-seq analysis for MDA-MB-468 cells treated with SAHA and sonidedgib
Epigenetic therapies that cause genome-wide epigenetic alterations, could trigger local interplay between different histone marks, leading to a switch of transcriptional outcome and cellular phenotypes. In human cancers with diverse oncogenic activation, how oncogenic pathways cooperate with epigene...
ORGANISM(S): Homo sapiens 
2024-10-18 | GSE187427 | GEO
GenomicsH3K27ac and H3K27me3 ChIP-seq analysis for MDA-MB-468 cells treated with SAHA and sonidedgib
Epigenetic therapies that cause genome-wide epigenetic alterations, could trigger local interplay between different histone marks, leading to a switch of transcriptional outcome and cellular phenotypes. In human cancers with diverse oncogenic activation, how oncogenic pathways cooperate with epigene...
ORGANISM(S): Homo sapiens 
2024-10-18 | GSE189215 | GEO
Sort   by:  
 Page size