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MetabolomicsDietary Glutamine Supplementation Mitigates Age-Associated Cardiac Decline by Restricting H3K27me3

Epigenetic alterations are central drivers of cardiovascular aging, with histone modifications regulating gene expression through chromatin remodeling and changes in DNA accessibility. However, the mechanisms underlying these epigenetic shifts in the aging heart remain poorly defined. Here, we id...

2026-02-11 | MTBLS13890 | MetaboLights
GenomicsJmjd3-mediated H3K27me3 dynamics orchestrate brown fat cell fate transition and regulate white fat plasticity
We performed ChIP-seq to chart genome-wide maps of H3K27me3 in brown preadipocytes and mature brown adipocytes. We observed a subset of brown fat-specific genes, but not common fat genes or white fat-specific genes, possess the H3K27me3 mark in preadipocytes, and this mark is erased in mature adipoc...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-55469 | biostudies-arrayexpress
TranscriptomicsThe X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex specific manner
This SuperSeries is composed of the following subset Series: GSE39472: X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner [ChIP-Seq data] GSE39473: The X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex specific manner [Agil...
ORGANISM(S): Mus musculus 
2012-07-31 | E-GEOD-39222 | biostudies-arrayexpress
ProteomicsA H3K27me3 reader complex couples H3K27me3 accumulation to nascent transcription of transposable elements in Paramecium
BackgroundThe ability to deposit histone H3K27-trimethyl (me3) marks is essential for transcriptional repression by Polycomb Repressive Complex 2 (PRC2). This is largely attributed to Polycomb repressive complex 1 (PRC1), whose recruitment is H3K27me3-dependent. Yet it is unclear how H3K27me3 contri...
ORGANISM(S): Paramecium tetraurelia 
2026-03-03 | PXD065449 | Pride
GenomicsGene specific signatures by H3K4me2 and H3K27me3 modifications during retina maturation
Control of neural organogenesis is a complex process and the epigenetic contribution is largely unknown. Here we have followed the genome-wide distribution of two important histone H3 modifications, H3K4me2 and H3K27me3 during late mouse retina development. We found that genes expressed only in matu...
ORGANISM(S): Mus musculus 
2012-12-13 | E-GEOD-38500 | biostudies-arrayexpress
GenomicsA Hierarchy of H3K4me3 and H3K27me3 Acquisition in Spatial Gene Regulation in Xenopus Embryos
Epigenetic mechanisms set apart the active and inactive regions in the genome of multicellular organisms to produce distinct cell fates during embryogenesis. Here, we report on the epigenetic and transcriptome genome-wide maps of gastrula-stage Xenopus tropicalis embryos using massive parallel seque...
ORGANISM(S): Xenopus (Silurana) tropicalis 
2009-09-15 | E-GEOD-14025 | biostudies-arrayexpress
GenomicsDistribution of histone modificiation H3K27me3 in Drosophila Kc cells, comparison with dCTCF knockdown
Here we map the localization of H3K27me3 in Drosophila Kc cells, as well as in Drosophila Kc cells wherein dCTCF is knock down. examination of genomic occupancy for H3K27me3, control samples used for Drosophila Kc were previously described (Wood, Van Bortle et al., 2011 GSE30740)
ORGANISM(S): Drosophila melanogaster 
2012-06-18 | E-GEOD-37444 | biostudies-arrayexpress
TranscriptomicsDNA methylation, H3K4me2, H3K27me3, Pol2 promoter profiling during neuronal differentiation
Cellular differentiation entails loss of pluripotency and parallel gain of lineage-specific and ultimately cell-type specific characteristics. Using a murine system that progresses from stem cells to lineage-committed progenitors and further to terminally differentiated neurons we analyzed two repre...
ORGANISM(S): Mus musculus 
2008-06-04 | E-GEOD-11489 | biostudies-arrayexpress
TranscriptomicsChip-chip from MEF cells with H3ac, H4ac, H4K20me1, H3K27me3, H3K9me3, H4K20me3, H3K4me2, H3K4me3 and H3K9ac
Genome wide chromatin maps have shown that spreading repressive histone modifications such as H3K9me3 and H4K20me3 are present on pericentromeric and telomeric repeats and on the inactive X chromosome where H3K27me3 or H3K9me3 alternately modify megabasepair sized domains. However, only a few region...
ORGANISM(S): Mus musculus 
2008-11-23 | E-GEOD-11335 | biostudies-arrayexpress
GenomicsChip-seq from MEF cells H3K27me3
Genome wide chromatin maps have shown that spreading repressive histone modifications such as H3K9me3 and H4K20me3 are present on pericentromeric and telomeric repeats and on the inactive X chromosome where H3K27me3 or H3K9me3 alternately modify megabasepair sized domains. However, only a few region...
ORGANISM(S): Mus musculus 
2008-12-22 | E-GEOD-12721 | biostudies-arrayexpress
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