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TranscriptomicsH3K36 mutations promote sarcomagenesis through genome-wide remodeling of H3K36 and H3K27 methylation [RNA_Chondroblastoma_H3K36M_H3WT]
The goal of this study is to understand the genome-wide alterations in chromatin landscapy induced by a histone mutation (H3.3 K36M) derived from chondroblastomas Examination of H3K36M mutations to H3WT Chondroblastomas.
ORGANISM(S): Homo sapiens 
2016-05-13 | E-GEOD-75853 | biostudies-arrayexpress
TranscriptomicsHistone H3K36M mutation impairs mesenchymal differentiation and drives sarcoma development [RNA_H33_K36M_HMT]
The goal of this study is to understand the alterations in transcriptome induced by histone H3K36M mutations
ORGANISM(S): Mus musculus 
2016-05-13 | GSE69285 | GEO
GenomicsHistone H3K36M mutation impairs mesenchymal differentiation and drives sarcoma development
Histone H3K36M mutation impairs mesenchymal differentiation and drives sarcoma development
PRJNA266967 | ENA
GenomicsThe H3K36M oncohistone inhibits NSD2 to activate a SETD2-dependent antiviral-like immune response in KRAS-driven lung cancer
The H3K36M oncohistone inhibits NSD2 to activate a SETD2-dependent antiviral-like immune response in KRAS-driven lung cancer
PRJNA1477583 | ENA
GenomicsMus musculus
Histone H3K36M mutation impairs mesenchymal differentiation and drives sarcoma development [RNA_H33_K36M_HMT]
PRJNA285080 | ENA
OtherThe H3K36M oncohistone inhibits NSD2 to activate a SETD2-dependent antiviral-like immune response in KRAS-driven lung cancer
Mutations in histone 3 at or near lysine 36 (H3K36) have dominantly acting oncogenic effects in multiple tumor types by limiting H3K36-directed methyltransferases. Paradoxically, we find that expression of the H3K36M oncohistone unexpectedly inhibits tumor formation in KRAS-driven lung adenocarcinom...
ORGANISM(S): Mus musculus 
2026-07-21 | GSE335211 | GEO
UnknownMethylation of histone H3 lysine 36 is a barrier for therapeutic interventions of head and neck squamous cell carcinoma.
Not available
S-EPMC10705544 | biostudies-literature
TranscriptomicsDepletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function
Histone tails are post-translationally modified at multiple sites, including Lys36 on histone H3 (H3K36). The H3K36 methylation has been shown to associate with the transcription of active euchromatin, alternative splicing, DNA repair and recombination. However, the role of H3K36 methylation during ...
ORGANISM(S): Mus musculus 
2018-03-19 | GSE83793 | GEO
TranscriptomicsRNA-seq data for lineage negative, Sca1 positive, and cKit positive hematopoietic stem/progenitor cells from H3.3K36M, H3.3K9M, or rtTA control mice
We analyzed gene expression patterns in LKS cells using RNA-seq after one week of mutant histone induction. We chose this time point to minimize secondary effects and because methylation at both H3K9 and H3K36 is maximally depleted by that time. Compared to rtTA control, 150 and 364 genes were diffe...
ORGANISM(S): Mus musculus 
2020-09-04 | GSE103521 | GEO
UnknownMolecular basis for the role of oncogenic histone mutations in modulating H3K36 methylation.
Not available
S-EPMC5335568 | biostudies-literature
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