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MetabolomicsGluconeogenic enzyme PCK1 supports S-adenosylmethionine biosynthesis and H3K9me3 to suppress HCC progression
Deciphering the crosstalk between metabolic reprogramming and epigenetic regulation is a promising strategy for cancer therapy. In this study, we discovered that the gluconeogenic enzyme PCK1 fuels the generation of S-adenosylmethionine (SAM) through the serine synthesis pathway. The methyltransfera...
2025-08-09 | MTBLS7651 | MetaboLights
GenomicsHP1 dimerization drives the condensation and segregation of H3K9me-marked chromatin
HP1 dimerization drives the condensation and segregation of H3K9me-marked chromatin
PRJNA1498350 | ENA
UnknownH3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity.
Not available
S-EPMC8572725 | biostudies-literature
GenomicsHP1 dimerization drives the condensation and segregation of H3K9me-marked chromatin [RNA-seq]
HP1 dimerization drives the condensation and segregation of H3K9me-marked chromatin [RNA-seq]
PRJNA1505562 | ENA
TranscriptomicsHP1a recruitment to promoters is independent of H3K9 methylation in Drosophila melanogaster
Heterochromatin protein 1 (HP1) proteins are important regulators of heterochromatin mediated gene silencing and chromosome structure and it is well known as the reader of the heterochromatin mark methylation of histone H3 lysine 9 (H3K9me). In Drosophila three different histone lysine methyl transf...
ORGANISM(S): Drosophila melanogaster 
2012-12-21 | E-GEOD-38366 | biostudies-arrayexpress
UnknownUnique roles for histone H3K9me states in RNAi and heritable silencing of transcription.
Not available
S-EPMC5576860 | biostudies-literature
UnknownSETDB1-like MET-2 promotes transcriptional silencing and development independently of its H3K9me-associated catalytic activity.
Not available
S-EPMC8850192 | biostudies-literature
GenomicsHP1 dimerization drives the condensation and segregation of H3K9me-marked chromatin
Heterochromatin protein 1 (HP1) is a conserved chromatin-associated factor implicated in the establishment and maintenance of H3K9me-marked heterochromatin, potentially through phase separation–mediated condensation. Whether HP1 promotes heterochromatin condensation primarily through its dimerizatio...
ORGANISM(S): Caenorhabditis elegans 
2026-08-25 | GSE339336 | GEO
GenomicsH3K9me blocks transcription factor activity in differentiated cells to ensure tissue integrity [ATAC-seq]
H3K9me blocks transcription factor activity in differentiated cells to ensure tissue integrity [ATAC-seq]
PRJNA703542 | ENA
UnknownPHF2-mediated H3K9me balance orchestrates heterochromatin stability and neural progenitor proliferation.
Not available
S-EPMC11315909 | biostudies-literature
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