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TranscriptomicsGenome-wide analysis of tumor regression upon K-RAS inactivation
We performed expression profiling on micro-dissected lung tumors derived from a doxycycline-inducible K-RAS mouse model in order to gain mechanistic insight into K-RAS-mediated tumor maintenance. In this model, the tumors were induced with doxycycline for 11 weeks (in order to obtain lung tumors). A...
ORGANISM(S): Mus musculus 
2012-09-06 | E-GEOD-40606 | biostudies-arrayexpress
TranscriptomicsExpression profiling of murine lung 70 days following exposure to fractionated or acute dose of 1.0 Gy 56Fe- particle irradiation
Irradiation of the K-rasLA1 mouse model with a fractionated dose of 1.0Gy 56Fe- particles increases the incidence of invasive carcinoma compared to unirradiated controls or those irradiated with an acute dose. Microarray profiling was perfromed on whole lungs from K-rasLA1 mice in order to determin...
ORGANISM(S): Mus musculus 
2014-09-22 | E-GEOD-42233 | biostudies-arrayexpress
UnknownSymptom Trajectories After an Emergency Department Visit for Potential Acute Coronary Syndrome.
Not available
S-EPMC4930007 | biostudies-literature
TranscriptomicsGene expression data from human metastatic melanoma tumors that may predict response to RAF265
To determine how mutation of BRAF affected the response to RAF265, we utilized a tumor orthotopic implant model of early passage melanoma tumors in nude mice from a series of 17 patients with advanced metastatic Tumor growth was compared between RAF265 treatment (40 mg/kg, QD) and diluent control gr...
ORGANISM(S): Homo sapiens 
2012-05-01 | E-GEOD-30812 | biostudies-arrayexpress
UnknownGenetic variants at the 16p13 locus confer risk for eosinophilic esophagitis.
Not available
S-EPMC6286696 | biostudies-literature
TranscriptomicsPromoter context-specific positive and negative transcriptional regulation of Glucocorticoid Receptor target genes by coregulator G9a
A549 lung cancer cells were not infected (NI), transfected by plasmids containing shG9a (sequence targeting G9a gene) or shNS (non-specific sequence). These cells were treated with dex to identify subsets of genes regulated by dex (hormone) and G9a (EHMT2) Cells (NI/shNS/shG9a) were treated with 100...
ORGANISM(S): Homo sapiens 
2012-11-02 | E-GEOD-35962 | biostudies-arrayexpress
TranscriptomicsSuppression and Activation of the Malignant Phenotype by Extracellular Matrix in Xenograft Models of Bladder Cancer: A Model for Tumor Cell Dormancy
A major problem in cancer research is the lack of a tractable model for delayed metastasis. Herein we show that cancer cells suppressed by SISgel, a gel-forming normal ECM material derived from Small Intestine Submucosa, in flank xenografts show properties of suppression and re-activation that are v...
ORGANISM(S): Homo sapiens 
2014-02-20 | E-GEOD-35947 | biostudies-arrayexpress
TranscriptomicsDiscovery of novel recurrent mutations and rearrangements in early T-cell precursor acute lymphoblastic leukemia by whole genome sequencing
Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive malignancy of unknown genetic basis. We performed whole genome sequencing of tumour and normal DNA from 12 children with ETP ALL and assessed the frequency of somatic alterations in 52 ETP and 42 non-ETP T-ALL samples by...
ORGANISM(S): Homo sapiens 
2011-11-23 | E-GEOD-28703 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of Dop1R2 RNAi in Drosophila melanogaster
The process of metamorphosis relies on choreography of temporal and spatial cues that mediate, in which inappropriate activation of many of these genes results in growth defects, developmental delay and death. Using RNA interference, we have unraveled an essential role for the insect specific dopam...
ORGANISM(S): Drosophila melanogaster 
2015-09-01 | E-GEOD-66496 | biostudies-arrayexpress
TranscriptomicsIntegrated transcriptomic and epigenomic analysis of primary human lung cell differentiation (Rat)
Analysis of gene expression during differentiation of alveolar epithelial type 2 (AT2) cells into AT1 cells. Timepoints taken at Day 0 (AT2 cell), Days 2, 4, and 6 in culture (differentiating) and Day 8 in culture (AT1-like cells). 1ug of RNA was subjected to cRNA conversion using Illumina TotalPrep...
ORGANISM(S): Rattus norvegicus 
2013-04-15 | E-GEOD-38570 | biostudies-arrayexpress
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