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TranscriptomicsLIN28A-mediated regulation of microRNA biogenesis in mouse embryonic stem cell (A3-1) [Agilent]
LIN28A is a highly-conserved RNA-binding protein which is known to be involved in embryonic development, stem cell maintenance and proliferation. LIN28A is expressed in various types of cancer, and they are associated with advanced tumor malignancy. In embryonic stem cell, LIN28A specifically binds ...
ORGANISM(S): Mus musculus 
2012-10-25 | E-GEOD-37112 | biostudies-arrayexpress
TranscriptomicsSmall RNA profiles following TUT knock-down in HeLa
The precise control of microRNA (miRNA) biogenesis is important for various cellular functions, and its dysregulation is often associated with human diseases. We previously reported that Terminal uridylyl transferase 4 (TUT4) down-regulates let-7 miRNA biogenesis by oligo-uridylating let-7 precursor...
ORGANISM(S): Homo sapiens 
2012-10-16 | E-GEOD-35835 | biostudies-arrayexpress
TranscriptomicsmRNA profiles following TUT knock-down in HeLa
The precise control of microRNA (miRNA) biogenesis is important for various cellular functions, and its dysregulation is often associated with human diseases. We previously reported that Terminal uridylyl transferase 4 (TUT4) down-regulates let-7 miRNA biogenesis by oligo-uridylating let-7 precur...
ORGANISM(S): Homo sapiens 
2012-10-16 | E-GEOD-40228 | biostudies-arrayexpress
TranscriptomicsPoly(A) tail length change of miRNA targets in HeLa cells
MicroRNA induces deadenylation of its targets according to the current model in the scientific community, but this model is based on the studies of a few individual genes. We tested the model by examining the global effect of miRNA on poly(A) tail of the targets. Synthetic miR-1 mimic was transfecte...
ORGANISM(S): Homo sapiens 
2014-02-28 | E-GEOD-54114 | biostudies-arrayexpress
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