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GenomicsGenome-wide analysis of H3.3 dissociation in mouse embryonic stem cells
Using Tet-inhibited expression of epitope-tagged H3.3 combined with ChIP-Seq we undertook genome-wide measurements of H3.3 dissociation rates across the ESC genome and examined the relationship between H3.3-nucleosome turnover and ESC-specific transcription factors, chromatin modifiers and epigeneti...
ORGANISM(S): Mus musculus 
2015-05-14 | E-GEOD-63641 | biostudies-arrayexpress
GenomicsGenome-wide incorporation dynamics reveal distinct categories of turnover for the histone variant H3.3
We developed a system to study the DNA replication-independent turnover nucleosomes containing the histone variant H3.3 in mammalian cells. By measuring the genome-wide incorporation of H3.3 at different time points following epitope-tagged H3.3 expression, we find three categories of H3.3-nucleosom...
ORGANISM(S): Mus musculus 
2013-10-23 | E-GEOD-51505 | biostudies-arrayexpress
GenomicsGenome-wide maps of histone modifications in Arabidopsis thaliana
Histone acetylation and methylation regulate gene expression in eukaryotes, but their effects on the transcriptome of a multicellular organism and on the transcriptomic divergence between species are still poorly understood. Here we present the first genome-wide 1-bp resolution maps of histone acety...
ORGANISM(S): Arabidopsis thaliana 
2011-02-02 | E-GEOD-22276 | biostudies-arrayexpress
TranscriptomicsSmall RNAs serve as a genetic buffer against genomic shock in Arabidopsis interspecific hybrids and allopolyploids
MicroRNAs (miRNAs) and small interfering RNAs (siRNAs) are produced in diverse species and control gene expression and epigenetic regulation. Although physiological and developmental roles of miRNAs and siRNAs have been extensively studied in plants and animals, expression diversity and evolution of...
ORGANISM(S): Arabidopsis arenosa 
2009-07-30 | E-GEOD-15443 | biostudies-arrayexpress
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